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The HIV-1 reverse transcriptase polymorphism A98S improves the response to tenofovir disoproxil fumarate+emtricitabine-containing HAART both in vivo and in vitro.
Alteri C, Surdo M, Di Maio VC, Di Santo F, Costa G, Parrotta L, Romeo I, Gori C, Santoro MM, Fedele V, Carta S, Continenza F, Pinnetti C, Bellagamba R, Liuzzi G, Orchi N, Latini A, Bertoli A, Girardi E, Alcaro S, Giuliani M, Petrosillo N, Andreoni M, Antinori A, Monforte AD, Ceccherini-Silberstein F, Artese A, Perno CF, Svicher V. Alteri C, et al. Among authors: romeo i. J Glob Antimicrob Resist. 2016 Dec;7:1-7. doi: 10.1016/j.jgar.2016.06.005. Epub 2016 Jul 25. J Glob Antimicrob Resist. 2016. PMID: 27530997
Pathway involving the N155H mutation in HIV-1 integrase leads to dolutegravir resistance.
Malet I, Ambrosio FA, Subra F, Herrmann B, Leh H, Bouger MC, Artese A, Katlama C, Talarico C, Romeo I, Alcaro S, Costa G, Deprez E, Calvez V, Marcelin AG, Delelis O. Malet I, et al. Among authors: romeo i. J Antimicrob Chemother. 2018 May 1;73(5):1158-1166. doi: 10.1093/jac/dkx529. J Antimicrob Chemother. 2018. PMID: 29373677
Design and Development of Biomimetic Nanovesicles Using a Microfluidic Approach.
Molinaro R, Evangelopoulos M, Hoffman JR, Corbo C, Taraballi F, Martinez JO, Hartman KA, Cosco D, Costa G, Romeo I, Sherman M, Paolino D, Alcaro S, Tasciotti E. Molinaro R, et al. Among authors: romeo i. Adv Mater. 2018 Apr;30(15):e1702749. doi: 10.1002/adma.201702749. Epub 2018 Mar 7. Adv Mater. 2018. PMID: 29512198
Novel natural non-nucleoside inhibitors of HIV-1 reverse transcriptase identified by shape- and structure-based virtual screening techniques.
Costa G, Rocca R, Corona A, Grandi N, Moraca F, Romeo I, Talarico C, Gagliardi MG, Ambrosio FA, Ortuso F, Alcaro S, Distinto S, Maccioni E, Tramontano E, Artese A. Costa G, et al. Among authors: romeo i. Eur J Med Chem. 2019 Jan 1;161:1-10. doi: 10.1016/j.ejmech.2018.10.029. Epub 2018 Oct 13. Eur J Med Chem. 2019. PMID: 30342421
Chromenone derivatives as a versatile scaffold with dual mode of inhibition of HIV-1 reverse transcriptase-associated Ribonuclease H function and integrase activity.
Esposito F, Ambrosio FA, Maleddu R, Costa G, Rocca R, Maccioni E, Catalano R, Romeo I, Eleftheriou P, Karia DC, Tsirides P, Godvani N, Pandya H, Corona A, Alcaro S, Artese A, Geronikaki A, Tramontano E. Esposito F, et al. Among authors: romeo i. Eur J Med Chem. 2019 Nov 15;182:111617. doi: 10.1016/j.ejmech.2019.111617. Epub 2019 Aug 12. Eur J Med Chem. 2019. PMID: 31442684
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