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The HIV-1 reverse transcriptase polymorphism A98S improves the response to tenofovir disoproxil fumarate+emtricitabine-containing HAART both in vivo and in vitro.
Alteri C, Surdo M, Di Maio VC, Di Santo F, Costa G, Parrotta L, Romeo I, Gori C, Santoro MM, Fedele V, Carta S, Continenza F, Pinnetti C, Bellagamba R, Liuzzi G, Orchi N, Latini A, Bertoli A, Girardi E, Alcaro S, Giuliani M, Petrosillo N, Andreoni M, Antinori A, Monforte AD, Ceccherini-Silberstein F, Artese A, Perno CF, Svicher V. Alteri C, et al. Among authors: romeo i. J Glob Antimicrob Resist. 2016 Dec;7:1-7. doi: 10.1016/j.jgar.2016.06.005. Epub 2016 Jul 25. J Glob Antimicrob Resist. 2016. PMID: 27530997
Pathway involving the N155H mutation in HIV-1 integrase leads to dolutegravir resistance.
Malet I, Ambrosio FA, Subra F, Herrmann B, Leh H, Bouger MC, Artese A, Katlama C, Talarico C, Romeo I, Alcaro S, Costa G, Deprez E, Calvez V, Marcelin AG, Delelis O. Malet I, et al. Among authors: romeo i. J Antimicrob Chemother. 2018 May 1;73(5):1158-1166. doi: 10.1093/jac/dkx529. J Antimicrob Chemother. 2018. PMID: 29373677
Design and Development of Biomimetic Nanovesicles Using a Microfluidic Approach.
Molinaro R, Evangelopoulos M, Hoffman JR, Corbo C, Taraballi F, Martinez JO, Hartman KA, Cosco D, Costa G, Romeo I, Sherman M, Paolino D, Alcaro S, Tasciotti E. Molinaro R, et al. Among authors: romeo i. Adv Mater. 2018 Apr;30(15):e1702749. doi: 10.1002/adma.201702749. Epub 2018 Mar 7. Adv Mater. 2018. PMID: 29512198
Real-life 3D therapy failure: Analysis of NS5A 93H RAS plus 108 K polymorphism in complex with ombitasvir by molecular modeling.
Marascio N, Pavia G, Romeo I, Talarico C, Di Salvo S, Reale M, Marano V, Barreca GS, Fabiani F, Perrotti N, De Siena M, Giancotti F, Gravina T, Alcaro S, Artese A, Torti C, Liberto MC, Focà A. Marascio N, et al. Among authors: romeo i. J Med Virol. 2018 Jul;90(7):1257-1263. doi: 10.1002/jmv.25073. Epub 2018 Mar 31. J Med Virol. 2018. PMID: 29575060
New resistance mutations to nucleoside reverse transcriptase inhibitors at codon 184 of HIV-1 reverse transcriptase (M184L and M184T).
Pouga L, Santoro MM, Charpentier C, Di Carlo D, Romeo I, Artese A, Alcaro S, Antinori A, Wirden M, Perno CF, Ambrosio FA, Calvez V, Descamps D, Marcelin AG, Ceccherini-Silberstein F, Lambert-Niclot S. Pouga L, et al. Among authors: romeo i. Chem Biol Drug Des. 2019 Jan;93(1):50-59. doi: 10.1111/cbdd.13378. Epub 2018 Nov 27. Chem Biol Drug Des. 2019. PMID: 30103267
Novel natural non-nucleoside inhibitors of HIV-1 reverse transcriptase identified by shape- and structure-based virtual screening techniques.
Costa G, Rocca R, Corona A, Grandi N, Moraca F, Romeo I, Talarico C, Gagliardi MG, Ambrosio FA, Ortuso F, Alcaro S, Distinto S, Maccioni E, Tramontano E, Artese A. Costa G, et al. Among authors: romeo i. Eur J Med Chem. 2019 Jan 1;161:1-10. doi: 10.1016/j.ejmech.2018.10.029. Epub 2018 Oct 13. Eur J Med Chem. 2019. PMID: 30342421
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