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Vemurafenib acts as an aryl hydrocarbon receptor antagonist: Implications for inflammatory cutaneous adverse events.
Hawerkamp HC, Kislat A, Gerber PA, Pollet M, Rolfes KM, Soshilov AA, Denison MS, Momin AA, Arold ST, Datsi A, Braun SA, Oláh P, Lacouture ME, Krutmann J, Haarmann-Stemmann T, Homey B, Meller S. Hawerkamp HC, et al. Among authors: rolfes km. Allergy. 2019 Dec;74(12):2437-2448. doi: 10.1111/all.13972. Epub 2019 Sep 3. Allergy. 2019. PMID: 31269229 Free PMC article.
Extended Multicomponent Reactions with Indole Aldehydes: Access to Unprecedented Polyheterocyclic Scaffolds, Ligands of the Aryl Hydrocarbon Receptor.
Ghashghaei O, Pedrola M, Seghetti F, Martin VV, Zavarce R, Babiak M, Novacek J, Hartung F, Rolfes KM, Haarmann-Stemmann T, Lavilla R. Ghashghaei O, et al. Among authors: rolfes km. Angew Chem Int Ed Engl. 2021 Feb 1;60(5):2603-2608. doi: 10.1002/anie.202011253. Epub 2020 Nov 26. Angew Chem Int Ed Engl. 2021. PMID: 33048416
Unraveling the differential impact of PAHs and dioxin-like compounds on AKR1C3 reveals the EGFR extracellular domain as a critical determinant of the AHR response.
Vogeley C, Sondermann NC, Woeste S, Momin AA, Gilardino V, Hartung F, Heinen M, Maaß SK, Mescher M, Pollet M, Rolfes KM, Vogel CFA, Rossi A, Lang D, Arold ST, Nakamura M, Haarmann-Stemmann T. Vogeley C, et al. Among authors: rolfes km. Environ Int. 2022 Jan;158:106989. doi: 10.1016/j.envint.2021.106989. Epub 2021 Nov 20. Environ Int. 2022. PMID: 34991250 Free PMC article.
Monoterpenoid aryl hydrocarbon receptor allosteric antagonists protect against ultraviolet skin damage in female mice.
Ondrová K, Zůvalová I, Vyhlídalová B, Krasulová K, Miková E, Vrzal R, Nádvorník P, Nepal B, Kortagere S, Kopečná M, Kopečný D, Šebela M, Rastinejad F, Pu H, Soural M, Rolfes KM, Haarmann-Stemmann T, Li H, Mani S, Dvořák Z. Ondrová K, et al. Among authors: rolfes km. Nat Commun. 2023 May 11;14(1):2728. doi: 10.1038/s41467-023-38478-6. Nat Commun. 2023. PMID: 37169746 Free PMC article.