Roleira FM - Search Results

1

New steroidal 17β-carboxy derivatives present anti-5α-reductase activity and anti-proliferative effects in a human androgen-responsive prostate cancer cell line.

Amaral C, Varela C, Correia-da-Silva G, Tavares da Silva E, Carvalho RA, Costa SC, Cunha SC, Fernandes JO, Teixeira N, Roleira FM. Amaral C, et al. Among authors: roleira fm. Biochimie. 2013 Nov;95(11):2097-106. doi: 10.1016/j.biochi.2013.07.023. Epub 2013 Aug 9. Biochimie. 2013. PMID: 23933094

2

Structure-activity relationships of new A,D-ring modified steroids as aromatase inhibitors: design, synthesis, and biological activity evaluation.

Cepa MM, Tavares da Silva EJ, Correia-da-Silva G, Roleira FM, Teixeira NA. Cepa MM, et al. Among authors: roleira fm. J Med Chem. 2005 Oct 6;48(20):6379-85. doi: 10.1021/jm050129p. J Med Chem. 2005. PMID: 16190763 Free article.

3

New steroidal aromatase inhibitors: suppression of estrogen-dependent breast cancer cell proliferation and induction of cell death.

Cepa M, Correia-da-Silva G, da Silva EJ, Roleira FM, Borges M, Teixeira NA. Cepa M, et al. Among authors: roleira fm. BMC Cell Biol. 2008 Jul 24;9:41. doi: 10.1186/1471-2121-9-41. BMC Cell Biol. 2008. PMID: 18652661 Free PMC article.

4

Synthesis and biochemical studies of 17-substituted androst-3-enes and 3,4-epoxyandrostanes as aromatase inhibitors.

Cepa MM, Tavares da Silva EJ, Correia-da-Silva G, Roleira FM, Teixeira NA. Cepa MM, et al. Among authors: roleira fm. Steroids. 2008 Dec 22;73(14):1409-15. doi: 10.1016/j.steroids.2008.07.001. Epub 2008 Jul 17. Steroids. 2008. PMID: 18691607

5

Molecular mechanisms of aromatase inhibition by new A, D-ring modified steroids.

Cepa M, Correia-da-Silva G, Tavares da Silva EJ, Roleira FM, Hong Y, Chen S, Teixeira NA. Cepa M, et al. Among authors: roleira fm. Biol Chem. 2008 Sep;389(9):1183-91. doi: 10.1515/BC.2008.134. Biol Chem. 2008. PMID: 18713005

6

New structure-activity relationships of A- and D-ring modified steroidal aromatase inhibitors: design, synthesis, and biochemical evaluation.

Varela C, Tavares da Silva EJ, Amaral C, Correia da Silva G, Baptista T, Alcaro S, Costa G, Carvalho RA, Teixeira NA, Roleira FM. Varela C, et al. Among authors: roleira fm. J Med Chem. 2012 Apr 26;55(8):3992-4002. doi: 10.1021/jm300262w. Epub 2012 Apr 18. J Med Chem. 2012. PMID: 22475216

7

Effects of steroidal aromatase inhibitors on sensitive and resistant breast cancer cells: aromatase inhibition and autophagy.

Amaral C, Varela C, Azevedo M, da Silva ET, Roleira FM, Chen S, Correia-da-Silva G, Teixeira N. Amaral C, et al. Among authors: roleira fm. J Steroid Biochem Mol Biol. 2013 May;135:51-9. doi: 10.1016/j.jsbmb.2012.12.017. Epub 2013 Jan 11. J Steroid Biochem Mol Biol. 2013. PMID: 23318878

8

Design, synthesis and biochemical studies of new 7α-allylandrostanes as aromatase inhibitors.

Varela CL, Amaral C, Correia-da-Silva G, Carvalho RA, Teixeira NA, Costa SC, Roleira FM, Tavares-da-Silva EJ. Varela CL, et al. Among authors: roleira fm. Steroids. 2013 Jul;78(7):662-9. doi: 10.1016/j.steroids.2013.02.016. Epub 2013 Mar 13. Steroids. 2013. PMID: 23499824

9

Development of a new gas chromatography-mass spectrometry (GC-MS) methodology for the evaluation of 5α-reductase activity.

Amaral C, Cunha SC, Fernandes JO, Tavares da Silva E, Roleira FM, Teixeira N, Correia-da-Silva G. Amaral C, et al. Among authors: roleira fm. Talanta. 2013 Mar 30;107:154-61. doi: 10.1016/j.talanta.2012.12.045. Epub 2013 Jan 2. Talanta. 2013. PMID: 23598206

10

Steroidal aromatase inhibitors inhibit growth of hormone-dependent breast cancer cells by inducing cell cycle arrest and apoptosis.

Amaral C, Varela C, Borges M, Tavares da Silva E, Roleira FMF, Correia-da-Silva G, Teixeira N. Amaral C, et al. Apoptosis. 2013 Nov;18(11):1426-1436. doi: 10.1007/s10495-013-0879-6. Apoptosis. 2013. PMID: 23842740

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