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102 results

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LTA4H inhibitor LYS006: Clinical PK/PD and safety in a randomized phase I clinical trial.
Loesche C, Picard D, Van Hoorick B, Schuhmann I, Jäger P, Klein K, Schuhler C, Thoma G, Markert C, Poller B, Zamurovic N, Weiss HM, Otto H, Fink M, Röhn TA. Loesche C, et al. Among authors: rohn ta. Clin Transl Sci. 2024 Feb;17(2):e13724. doi: 10.1111/cts.13724. Clin Transl Sci. 2024. PMID: 38407540 Free PMC article. Clinical Trial.
IL-26 Potentiates Type 2 Skin Inflammation in the Presence of IL-1β.
Bier K, Senajova Z, Henrion F, Wang Y, Bruno S, Rauld C, Hörmann LC, Barske C, Delucis-Bronn C, Bergling S, Altorfer M, Hägele J, Knehr J, Junt T, Roediger B, Röhn TA, Kolbinger F. Bier K, et al. Among authors: rohn ta. J Invest Dermatol. 2024 Jan 17:S0022-202X(24)00017-4. doi: 10.1016/j.jid.2023.12.018. Online ahead of print. J Invest Dermatol. 2024. PMID: 38237730
Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase.
Thoma G, Markert C, Lueoend R, Miltz W, Spanka C, Bollbuck B, Wolf RM, Srinivas H, Penno CA, Kiffe M, Gajewska M, Bednarczyk D, Wieczorek G, Evans A, Beerli C, Röhn TA. Thoma G, et al. Among authors: rohn ta. J Med Chem. 2023 Dec 14;66(23):16410-16425. doi: 10.1021/acs.jmedchem.3c01866. Epub 2023 Nov 28. J Med Chem. 2023. PMID: 38015154
Genetic modulation of the HTR2A gene reduces anxiety-related behavior in mice.
Rohn TT, Radin D, Brandmeyer T, Linder BJ, Andriambeloson E, Wagner S, Kehler J, Vasileva A, Wang H, Mee JL, Fallon JH. Rohn TT, et al. PNAS Nexus. 2023 Jun 20;2(6):pgad170. doi: 10.1093/pnasnexus/pgad170. eCollection 2023 Jun. PNAS Nexus. 2023. PMID: 37346271 Free PMC article.
Adriforant is a functional antagonist of histamine receptor 4 and attenuates itch and skin inflammation in mice.
Uluckan Ö, Bruno S, Wang Y, Wack N, Wilzopolski J, Goetschy JF, Delucis-Bronn C, Urban B, Fehlmann D, Stark H, Hauchard A, Roussel E, Kempf D, Kaupmann K, Raulf F, Bäumer W, Röhn TA, Zerwes HG. Uluckan Ö, et al. Among authors: rohn ta. Eur J Pharmacol. 2023 Apr 15;945:175533. doi: 10.1016/j.ejphar.2023.175533. Epub 2023 Jan 21. Eur J Pharmacol. 2023. PMID: 36690055
Disease Association of Anti‒Carboxyethyl Lysine Autoantibodies in Hidradenitis Suppurativa.
Macchiarella G, Cornacchione V, Cojean C, Riker J, Wang Y, Te H, Ceci M, Gudjonsson JE, Gaulis S, Goetschy JF, Wollschlegel A, Gass SK, Oetliker-Contin S, Wettstein-Ling B, Schaefer DJ, Meschberger P, de Roche R, Osinga R, Wieczorek G, Naumann U, Lehmann JCU, Schubart A, Hofmann A, Roth L, Florencia EF, Loesche C, Traggiai E, Avrameas A, Prens EP, Röhn TA, Roediger B. Macchiarella G, et al. Among authors: rohn ta. J Invest Dermatol. 2023 Feb;143(2):273-283.e12. doi: 10.1016/j.jid.2022.08.051. Epub 2022 Sep 16. J Invest Dermatol. 2023. PMID: 36116506 Free article.
102 results