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EZH2 inhibition activates a dsRNA-STING-interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer.
Nat Cancer. 2021 Apr;2(4):444-456. doi: 10.1038/s43018-021-00185-w. Epub 2021 Mar 22.
Nat Cancer. 2021.
PMID: 33899001
Free PMC article.
Inhibition of CDK4/6 Promotes CD8 T-cell Memory Formation.
Heckler M, Ali LR, Clancy-Thompson E, Qiang L, Ventre KS, Lenehan P, Roehle K, Luoma A, Boelaars K, Peters V, McCreary J, Boschert T, Wang ES, Suo S, Marangoni F, Mempel TR, Long HW, Wucherpfennig KW, Dougan M, Gray NS, Yuan GC, Goel S, Tolaney SM, Dougan SK.
Heckler M, et al. Among authors: roehle k.
Cancer Discov. 2021 Oct;11(10):2564-2581. doi: 10.1158/2159-8290.CD-20-1540. Epub 2021 May 3.
Cancer Discov. 2021.
PMID: 33941591
Free PMC article.
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Radiation combines with immune checkpoint blockade to enhance T cell priming in a murine model of poorly immunogenic pancreatic cancer.
Stump CT, Roehle K, Manjarrez Orduno N, Dougan SK.
Stump CT, et al. Among authors: roehle k.
Open Biol. 2021 Nov;11(11):210245. doi: 10.1098/rsob.210245. Epub 2021 Nov 17.
Open Biol. 2021.
PMID: 34784792
Free PMC article.
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cIAP1/2 antagonism eliminates MHC class I-negative tumors through T cell-dependent reprogramming of mononuclear phagocytes.
Roehle K, Qiang L, Ventre KS, Heid D, Ali LR, Lenehan P, Heckler M, Crowley SJ, Stump CT, Ro G, Godicelj A, Bhuiyan AM, Yang A, Quiles Del Rey M, Biary T, Luoma AM, Bruck PT, Tegethoff JF, Nopper SL, Li J, Byrne KT, Pelletier M, Wucherpfennig KW, Stanger BZ, Akin JJ, Mancias JD, Agudo J, Dougan M, Dougan SK.
Roehle K, et al.
Sci Transl Med. 2021 May 19;13(594):eabf5058. doi: 10.1126/scitranslmed.abf5058.
Sci Transl Med. 2021.
PMID: 34011631
Free PMC article.
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HLA ligandomics identifies histone deacetylase 1 as target for ovarian cancer immunotherapy.
Peper JK, Bösmüller HC, Schuster H, Gückel B, Hörzer H, Roehle K, Schäfer R, Wagner P, Rammensee HG, Stevanović S, Fend F, Staebler A.
Peper JK, et al. Among authors: roehle k.
Oncoimmunology. 2015 Jul 1;5(5):e1065369. doi: 10.1080/2162402X.2015.1065369. eCollection 2016 May.
Oncoimmunology. 2015.
PMID: 27467910
Free PMC article.
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cIAP1/2 Antagonism Induces Antigen-Specific T Cell-Dependent Immunity.
Ventre KS, Roehle K, Bello E, Bhuiyan AM, Biary T, Crowley SJ, Bruck PT, Heckler M, Lenehan PJ, Ali LR, Stump CT, Lippert V, Clancy-Thompson E, Conce Alberto WD, Hoffman MT, Qiang L, Pelletier M, Akin JJ, Dougan M, Dougan SK.
Ventre KS, et al. Among authors: roehle k.
J Immunol. 2023 Apr 1;210(7):991-1003. doi: 10.4049/jimmunol.2200646.
J Immunol. 2023.
PMID: 36881882
Free PMC article.
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