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WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion.
Rodriguez-Hernandez I, Maiques O, Kohlhammer L, Cantelli G, Perdrix-Rosell A, Monger J, Fanshawe B, Bridgeman VL, Karagiannis SN, Penin RM, Marcolval J, Marti RM, Matias-Guiu X, Fruhwirth GO, Orgaz JL, Malanchi I, Sanz-Moreno V. Rodriguez-Hernandez I, et al. Nat Commun. 2020 Oct 20;11(1):5315. doi: 10.1038/s41467-020-18951-2. Nat Commun. 2020. PMID: 33082334 Free PMC article.
Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment.
Georgouli M, Herraiz C, Crosas-Molist E, Fanshawe B, Maiques O, Perdrix A, Pandya P, Rodriguez-Hernandez I, Ilieva KM, Cantelli G, Karagiannis P, Mele S, Lam H, Josephs DH, Matias-Guiu X, Marti RM, Nestle FO, Orgaz JL, Malanchi I, Fruhwirth GO, Karagiannis SN, Sanz-Moreno V. Georgouli M, et al. Cell. 2019 Feb 7;176(4):757-774.e23. doi: 10.1016/j.cell.2018.12.038. Epub 2019 Jan 31. Cell. 2019. PMID: 30712866 Free PMC article.
Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance.
Orgaz JL, Crosas-Molist E, Sadok A, Perdrix-Rosell A, Maiques O, Rodriguez-Hernandez I, Monger J, Mele S, Georgouli M, Bridgeman V, Karagiannis P, Lee R, Pandya P, Boehme L, Wallberg F, Tape C, Karagiannis SN, Malanchi I, Sanz-Moreno V. Orgaz JL, et al. Cancer Cell. 2020 Jan 13;37(1):85-103.e9. doi: 10.1016/j.ccell.2019.12.003. Cancer Cell. 2020. PMID: 31935375 Free PMC article.
A preclinical pipeline to evaluate migrastatics as therapeutic agents in metastatic melanoma.
Maiques O, Fanshawe B, Crosas-Molist E, Rodriguez-Hernandez I, Volpe A, Cantelli G, Boehme L, Orgaz JL, Mardakheh FK, Sanz-Moreno V, Fruhwirth GO. Maiques O, et al. Among authors: rodriguez hernandez i. Br J Cancer. 2021 Aug;125(5):699-713. doi: 10.1038/s41416-021-01442-6. Epub 2021 Jun 25. Br J Cancer. 2021. PMID: 34172930 Free PMC article.
Rho, ROCK and actomyosin contractility in metastasis as drug targets.
Rodriguez-Hernandez I, Cantelli G, Bruce F, Sanz-Moreno V. Rodriguez-Hernandez I, et al. F1000Res. 2016 Apr 29;5:F1000 Faculty Rev-783. doi: 10.12688/f1000research.7909.1. eCollection 2016. F1000Res. 2016. PMID: 27158478 Free PMC article. Review.
T-type calcium channels drive migration/invasion in BRAFV600E melanoma cells through Snail1.
Maiques O, Barceló C, Panosa A, Pijuan J, Orgaz JL, Rodriguez-Hernandez I, Matas-Nadal C, Tell G, Vilella R, Fabra A, Puig S, Sanz-Moreno V, Matias-Guiu X, Canti C, Herreros J, Marti RM, Macià A. Maiques O, et al. Pigment Cell Melanoma Res. 2018 Jul;31(4):484-495. doi: 10.1111/pcmr.12690. Epub 2018 Feb 18. Pigment Cell Melanoma Res. 2018. PMID: 29385656 Free article.
41 results