Rodríguez-Hornedo N - Search Results

1

Cocrystals to facilitate delivery of poorly soluble compounds beyond-rule-of-5.

Kuminek G, Cao F, Bahia de Oliveira da Rocha A, Gonçalves Cardoso S, Rodríguez-Hornedo N. Kuminek G, et al. Adv Drug Deliv Rev. 2016 Jun 1;101:143-166. doi: 10.1016/j.addr.2016.04.022. Epub 2016 Apr 29. Adv Drug Deliv Rev. 2016. PMID: 27137109 Free PMC article. Review.

2

Cocrystal Solubility Advantage and Dose/Solubility Ratio Diagrams: A Mechanistic Approach To Selecting Additives and Controlling Dissolution-Supersaturation-Precipitation Behavior.

Cavanagh KL, Kuminek G, Rodríguez-Hornedo N. Cavanagh KL, et al. Among authors: rodriguez hornedo n. Mol Pharm. 2020 Nov 2;17(11):4286-4301. doi: 10.1021/acs.molpharmaceut.0c00713. Epub 2020 Oct 19. Mol Pharm. 2020. PMID: 32815731

3

How cocrystals of weakly basic drugs and acidic coformers might modulate solubility and stability.

Kuminek G, Rodríguez-Hornedo N, Siedler S, Rocha HV, Cuffini SL, Cardoso SG. Kuminek G, et al. Chem Commun (Camb). 2016 Apr 30;52(34):5832-5. doi: 10.1039/c6cc00898d. Epub 2016 Apr 4. Chem Commun (Camb). 2016. PMID: 27042997 Free PMC article.

4

Mechanistic Analysis of Cocrystal Dissolution as a Function of pH and Micellar Solubilization.

Cao F, Amidon GL, Rodriguez-Hornedo N, Amidon GE. Cao F, et al. Mol Pharm. 2016 Mar 7;13(3):1030-46. doi: 10.1021/acs.molpharmaceut.5b00862. Epub 2016 Feb 15. Mol Pharm. 2016. PMID: 26877267 Free PMC article.

5

Mechanistic Basis of Cocrystal Dissolution Advantage.

Cao F, Amidon GL, Rodríguez-Hornedo N, Amidon GE. Cao F, et al. J Pharm Sci. 2018 Jan;107(1):380-389. doi: 10.1016/j.xphs.2017.09.014. Epub 2017 Oct 6. J Pharm Sci. 2018. PMID: 28989017 Free PMC article.

6

Mechanistic Analysis of Cocrystal Dissolution, Surface pH, and Dissolution Advantage as a Guide for Rational Selection.

Cao F, Rodriguez-Hornedo N, Amidon GE. Cao F, et al. J Pharm Sci. 2019 Jan;108(1):243-251. doi: 10.1016/j.xphs.2018.09.028. Epub 2018 Sep 29. J Pharm Sci. 2019. PMID: 30278187 Free PMC article.

7

Cocrystal Solubility Advantage Diagrams as a Means to Control Dissolution, Supersaturation, and Precipitation.

Huang Y, Kuminek G, Roy L, Cavanagh KL, Yin Q, Rodríguez-Hornedo N. Huang Y, et al. Among authors: rodriguez hornedo n. Mol Pharm. 2019 Sep 3;16(9):3887-3895. doi: 10.1021/acs.molpharmaceut.9b00501. Epub 2019 Jul 31. Mol Pharm. 2019. PMID: 31318567 Free PMC article.

8

Synchronization of Cocrystal Dissolution and Drug Precipitation to Sustain Drug Supersaturation.

Cogo Machado T, Kavanagh ON, Gonçalves Cardoso S, Rodríguez-Hornedo N. Cogo Machado T, et al. Among authors: rodriguez hornedo n. Mol Pharm. 2022 Aug 1;19(8):2765-2775. doi: 10.1021/acs.molpharmaceut.2c00122. Epub 2022 Jul 14. Mol Pharm. 2022. PMID: 35833828

9

The role of pH and dose/solubility ratio on cocrystal dissolution, drug supersaturation and precipitation.

Machado TC, Kuminek G, Cardoso SG, Rodríguez-Hornedo N. Machado TC, et al. Among authors: rodriguez hornedo n. Eur J Pharm Sci. 2020 Sep 1;152:105422. doi: 10.1016/j.ejps.2020.105422. Epub 2020 Jun 10. Eur J Pharm Sci. 2020. PMID: 32531350

10

Evaluation and optimized selection of supersaturating drug delivery systems of posaconazole (BCS class 2b) in the gastrointestinal simulator (GIS): An in vitro-in silico-in vivo approach.

Hens B, Bermejo M, Tsume Y, Gonzalez-Alvarez I, Ruan H, Matsui K, Amidon GE, Cavanagh KL, Kuminek G, Benninghoff G, Fan J, Rodríguez-Hornedo N, Amidon GL. Hens B, et al. Eur J Pharm Sci. 2018 Mar 30;115:258-269. doi: 10.1016/j.ejps.2018.01.039. Eur J Pharm Sci. 2018. PMID: 29378253

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