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Chemokine CXCL12 uses CXCR4 and a signaling core formed by bifunctional Akt, extracellular signal-regulated kinase (ERK)1/2, and mammalian target of rapamycin complex 1 (mTORC1) proteins to control chemotaxis and survival simultaneously in mature dendritic cells.
Delgado-Martín C, Escribano C, Pablos JL, Riol-Blanco L, Rodríguez-Fernández JL. Delgado-Martín C, et al. J Biol Chem. 2011 Oct 28;286(43):37222-36. doi: 10.1074/jbc.M111.294116. Epub 2011 Aug 30. J Biol Chem. 2011. PMID: 21878648 Free PMC article.
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