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Telomerase-targeting compounds Imetelstat and 6-thio-dG act synergistically with chemotherapy in high-risk neuroblastoma models.
Fischer-Mertens J, Otte F, Roderwieser A, Rosswog C, Kahlert Y, Werr L, Hellmann AM, Berding M, Chiu B, Bartenhagen C, Fischer M. Fischer-Mertens J, et al. Among authors: roderwieser a. Cell Oncol (Dordr). 2022 Oct;45(5):991-1003. doi: 10.1007/s13402-022-00702-8. Epub 2022 Aug 12. Cell Oncol (Dordr). 2022. PMID: 35953764 Free PMC article.
Telomerase Is a Prognostic Marker of Poor Outcome and a Therapeutic Target in Neuroblastoma.
Roderwieser A, Sand F, Walter E, Fischer J, Gecht J, Bartenhagen C, Ackermann S, Otte F, Welte A, Kahlert Y, Lieberz D, Hertwig F, Reinhardt HC, Simon T, Peifer M, Ortmann M, Büttner R, Hero B, O'Sullivan RJ, Berthold F, Fischer M. Roderwieser A, et al. JCO Precis Oncol. 2019 Dec;3:1-20. doi: 10.1200/PO.19.00072. JCO Precis Oncol. 2019. PMID: 35100718
A mechanistic classification of clinical phenotypes in neuroblastoma.
Ackermann S, Cartolano M, Hero B, Welte A, Kahlert Y, Roderwieser A, Bartenhagen C, Walter E, Gecht J, Kerschke L, Volland R, Menon R, Heuckmann JM, Gartlgruber M, Hartlieb S, Henrich KO, Okonechnikov K, Altmüller J, Nürnberg P, Lefever S, de Wilde B, Sand F, Ikram F, Rosswog C, Fischer J, Theissen J, Hertwig F, Singhi AD, Simon T, Vogel W, Perner S, Krug B, Schmidt M, Rahmann S, Achter V, Lang U, Vokuhl C, Ortmann M, Büttner R, Eggert A, Speleman F, O'Sullivan RJ, Thomas RK, Berthold F, Vandesompele J, Schramm A, Westermann F, Schulte JH, Peifer M, Fischer M. Ackermann S, et al. Among authors: roderwieser a. Science. 2018 Dec 7;362(6419):1165-1170. doi: 10.1126/science.aat6768. Science. 2018. PMID: 30523111 Free PMC article.