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Page 1
TLR7 gain-of-function genetic variation causes human lupus.
Brown GJ, Cañete PF, Wang H, Medhavy A, Bones J, Roco JA, He Y, Qin Y, Cappello J, Ellyard JI, Bassett K, Shen Q, Burgio G, Zhang Y, Turnbull C, Meng X, Wu P, Cho E, Miosge LA, Andrews TD, Field MA, Tvorogov D, Lopez AF, Babon JJ, López CA, Gónzalez-Murillo Á, Garulo DC, Pascual V, Levy T, Mallack EJ, Calame DG, Lotze T, Lupski JR, Ding H, Ullah TR, Walters GD, Koina ME, Cook MC, Shen N, de Lucas Collantes C, Corry B, Gantier MP, Athanasopoulos V, Vinuesa CG. Brown GJ, et al. Among authors: roco ja. Nature. 2022 May;605(7909):349-356. doi: 10.1038/s41586-022-04642-z. Epub 2022 Apr 27. Nature. 2022. PMID: 35477763 Free PMC article.
Germinal Center Lymphocyte Ratios and Successful HIV Vaccines.
Gonzalez-Figueroa P, Roco JA, Vinuesa CG. Gonzalez-Figueroa P, et al. Among authors: roco ja. Trends Mol Med. 2017 Feb;23(2):95-97. doi: 10.1016/j.molmed.2016.12.009. Epub 2017 Jan 12. Trends Mol Med. 2017. PMID: 28089302
Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus.
Jiang SH, Athanasopoulos V, Ellyard JI, Chuah A, Cappello J, Cook A, Prabhu SB, Cardenas J, Gu J, Stanley M, Roco JA, Papa I, Yabas M, Walters GD, Burgio G, McKeon K, Byers JM, Burrin C, Enders A, Miosge LA, Canete PF, Jelusic M, Tasic V, Lungu AC, Alexander SI, Kitching AR, Fulcher DA, Shen N, Arsov T, Gatenby PA, Babon JJ, Mallon DF, de Lucas Collantes C, Stone EA, Wu P, Field MA, Andrews TD, Cho E, Pascual V, Cook MC, Vinuesa CG. Jiang SH, et al. Among authors: roco ja. Nat Commun. 2019 May 17;10(1):2201. doi: 10.1038/s41467-019-10242-9. Nat Commun. 2019. PMID: 31101814 Free PMC article.
Regulatory roles of IL-10-producing human follicular T cells.
Cañete PF, Sweet RA, Gonzalez-Figueroa P, Papa I, Ohkura N, Bolton H, Roco JA, Cuenca M, Bassett KJ, Sayin I, Barry E, Lopez A, Canaday DH, Meyer-Hermann M, Doglioni C, Fazekas de St Groth B, Sakaguchi S, Cook MC, Vinuesa CG. Cañete PF, et al. Among authors: roco ja. J Exp Med. 2019 Aug 5;216(8):1843-1856. doi: 10.1084/jem.20190493. Epub 2019 Jun 17. J Exp Med. 2019. PMID: 31209070 Free PMC article.
Class-Switch Recombination Occurs Infrequently in Germinal Centers.
Roco JA, Mesin L, Binder SC, Nefzger C, Gonzalez-Figueroa P, Canete PF, Ellyard J, Shen Q, Robert PA, Cappello J, Vohra H, Zhang Y, Nowosad CR, Schiepers A, Corcoran LM, Toellner KM, Polo JM, Meyer-Hermann M, Victora GD, Vinuesa CG. Roco JA, et al. Immunity. 2019 Aug 20;51(2):337-350.e7. doi: 10.1016/j.immuni.2019.07.001. Epub 2019 Jul 30. Immunity. 2019. PMID: 31375460 Free PMC article.
Follicular regulatory T cells produce neuritin to regulate B cells.
Gonzalez-Figueroa P, Roco JA, Papa I, Núñez Villacís L, Stanley M, Linterman MA, Dent A, Canete PF, Vinuesa CG. Gonzalez-Figueroa P, et al. Among authors: roco ja. Cell. 2021 Apr 1;184(7):1775-1789.e19. doi: 10.1016/j.cell.2021.02.027. Epub 2021 Mar 11. Cell. 2021. PMID: 33711260 Free article.
Extrafollicular Plasmablasts Present in the Acute Phase of Infections Express High Levels of PD-L1 and Are Able to Limit T Cell Response.
Serrán MG, Vernengo FF, Almada L, Beccaria CG, Gazzoni Y, Canete PF, Roco JA, Boari JT, Ramello MC, Wehrens E, Cai Y, Zuniga EI, Montes CL, Cockburn IA, Rodriguez EVA, Vinuesa CG, Gruppi A. Serrán MG, et al. Among authors: roco ja. Front Immunol. 2022 May 16;13:828734. doi: 10.3389/fimmu.2022.828734. eCollection 2022. Front Immunol. 2022. PMID: 35651611 Free PMC article.
Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation.
Chen Z, Cui Y, Yao Y, Liu B, Yunis J, Gao X, Wang N, Cañete PF, Tuong ZK, Sun H, Wang H, Yang S, Wang R, Leong YA, Simon Davis D, Qin J, Liang K, Deng J, Wang CK, Huang YH, Roco JA, Nettelfield S, Zhu H, Xu H, Yu Z, Craik D, Liu Z, Qi H, Parish C, Yu D. Chen Z, et al. Among authors: roco ja. Sci Immunol. 2023 Feb 24;8(80):eadd1728. doi: 10.1126/sciimmunol.add1728. Epub 2023 Feb 17. Sci Immunol. 2023. PMID: 36800411
Zeb2 drives the formation of CD11c+ atypical B cells to sustain germinal centers that control persistent infection.
Gao X, Shen Q, Roco JA, Dalton B, Frith K, Munier CML, Ballard FD, Wang K, Kelly HG, Nekrasov M, He JS, Jaeger R, Carreira P, Ellyard JI, Beattie L, Enders A, Cook MC, Zaunders JJ, Cockburn IA. Gao X, et al. Among authors: roco ja. Sci Immunol. 2024 Mar 29;9(93):eadj4748. doi: 10.1126/sciimmunol.adj4748. Epub 2024 Mar 29. Sci Immunol. 2024. PMID: 38330097
Harnessing DNA-induced immune responses for improving cancer vaccines.
Herrada AA, Rojas-Colonelli N, González-Figueroa P, Roco J, Oyarce C, Ligtenberg MA, Lladser A. Herrada AA, et al. Hum Vaccin Immunother. 2012 Nov 1;8(11):1682-93. doi: 10.4161/hv.22345. Epub 2012 Oct 30. Hum Vaccin Immunother. 2012. PMID: 23111166 Free PMC article. Review.
11 results