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Lipid conjugation of TLR7 agonist Resiquimod ensures co-delivery with the liposomal Cationic Adjuvant Formulation 01 (CAF01) but does not enhance immunopotentiation compared to non-conjugated Resiquimod+CAF01.
Wilkinson A, Lattmann E, Roces CB, Pedersen GK, Christensen D, Perrie Y. Wilkinson A, et al. Among authors: roces cb. J Control Release. 2018 Dec 10;291:1-10. doi: 10.1016/j.jconrel.2018.10.002. Epub 2018 Oct 3. J Control Release. 2018. PMID: 30291987 Free article.
Manufacturing Methods for Liposome Adjuvants.
Perrie Y, Kastner E, Khadke S, Roces CB, Stone P. Perrie Y, et al. Among authors: roces cb. Methods Mol Biol. 2017;1494:127-144. doi: 10.1007/978-1-4939-6445-1_9. Methods Mol Biol. 2017. PMID: 27718190
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