Robinson P - Search Results

1

Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia.

Moreira LM, Takawale A, Hulsurkar M, Menassa DA, Antanaviciute A, Lahiri SK, Mehta N, Evans N, Psarros C, Robinson P, Sparrow AJ, Gillis MA, Ashley N, Naud P, Barallobre-Barreiro J, Theofilatos K, Lee A, Norris M, Clarke MV, Russell PK, Casadei B, Bhattacharya S, Zajac JD, Davey RA, Sirois M, Mead A, Simmons A, Mayr M, Sayeed R, Krasopoulos G, Redwood C, Channon KM, Tardif JC, Wehrens XHT, Nattel S, Reilly S. Moreira LM, et al. Among authors: robinson p. Nature. 2020 Nov;587(7834):460-465. doi: 10.1038/s41586-020-2890-8. Epub 2020 Nov 4. Nature. 2020. PMID: 33149301

2

Effects of troponin C isoform on the action of the cardiotonic agent EMD 57033.

Lipscomb S, Preston LC, Robinson P, Redwood CS, Mulligan IP, Ashley CC. Lipscomb S, et al. Among authors: robinson p. Biochem J. 2005 Jun 15;388(Pt 3):905-12. doi: 10.1042/BJ20041841. Biochem J. 2005. PMID: 15705058 Free PMC article.

3

Functional effects of the DCM mutant Gly159Asp troponin C in skinned muscle fibres.

Preston LC, Lipscomb S, Robinson P, Mogensen J, McKenna WJ, Watkins H, Ashley CC, Redwood CS. Preston LC, et al. Among authors: robinson p. Pflugers Arch. 2007 Mar;453(6):771-6. doi: 10.1007/s00424-006-0161-7. Epub 2006 Sep 26. Pflugers Arch. 2007. PMID: 17021793

4

Mutations in fast skeletal troponin I, troponin T, and beta-tropomyosin that cause distal arthrogryposis all increase contractile function.

Robinson P, Lipscomb S, Preston LC, Altin E, Watkins H, Ashley CC, Redwood CS. Robinson P, et al. FASEB J. 2007 Mar;21(3):896-905. doi: 10.1096/fj.06-6899com. Epub 2006 Dec 27. FASEB J. 2007. PMID: 17194691

5

Dilated and hypertrophic cardiomyopathy mutations in troponin and alpha-tropomyosin have opposing effects on the calcium affinity of cardiac thin filaments.

Robinson P, Griffiths PJ, Watkins H, Redwood CS. Robinson P, et al. Circ Res. 2007 Dec 7;101(12):1266-73. doi: 10.1161/CIRCRESAHA.107.156380. Epub 2007 Oct 11. Circ Res. 2007. PMID: 17932326

6

Alpha-tropomyosin mutations in inherited cardiomyopathies.

Redwood C, Robinson P. Redwood C, et al. Among authors: robinson p. J Muscle Res Cell Motil. 2013 Aug;34(3-4):285-94. doi: 10.1007/s10974-013-9358-5. Epub 2013 Sep 5. J Muscle Res Cell Motil. 2013. PMID: 24005378 Review.

7

Hypertrophic cardiomyopathy mutations increase myofilament Ca²⁺ buffering, alter intracellular Ca²⁺ handling, and stimulate Ca²⁺-dependent signaling.

Robinson P, Liu X, Sparrow A, Patel S, Zhang YH, Casadei B, Watkins H, Redwood C. Robinson P, et al. J Biol Chem. 2018 Jul 6;293(27):10487-10499. doi: 10.1074/jbc.RA118.002081. Epub 2018 May 14. J Biol Chem. 2018. PMID: 29760186 Free PMC article.

8

Measurement of Myofilament-Localized Calcium Dynamics in Adult Cardiomyocytes and the Effect of Hypertrophic Cardiomyopathy Mutations.

Sparrow AJ, Sievert K, Patel S, Chang YF, Broyles CN, Brook FA, Watkins H, Geeves MA, Redwood CS, Robinson P, Daniels MJ. Sparrow AJ, et al. Among authors: robinson p. Circ Res. 2019 Apr 12;124(8):1228-1239. doi: 10.1161/CIRCRESAHA.118.314600. Circ Res. 2019. PMID: 30732532 Free PMC article.

9

Mavacamten rescues increased myofilament calcium sensitivity and dysregulation of Ca²⁺ flux caused by thin filament hypertrophic cardiomyopathy mutations.

Sparrow AJ, Watkins H, Daniels MJ, Redwood C, Robinson P. Sparrow AJ, et al. Among authors: robinson p. Am J Physiol Heart Circ Physiol. 2020 Mar 1;318(3):H715-H722. doi: 10.1152/ajpheart.00023.2020. Epub 2020 Feb 21. Am J Physiol Heart Circ Physiol. 2020. PMID: 32083971 Free PMC article.

10

Dilated cardiomyopathy mutations in thin-filament regulatory proteins reduce contractility, suppress systolic Ca²⁺, and activate NFAT and Akt signaling.

Robinson P, Sparrow AJ, Patel S, Malinowska M, Reilly SN, Zhang YH, Casadei B, Watkins H, Redwood C. Robinson P, et al. Am J Physiol Heart Circ Physiol. 2020 Aug 1;319(2):H306-H319. doi: 10.1152/ajpheart.00272.2020. Epub 2020 Jul 3. Am J Physiol Heart Circ Physiol. 2020. PMID: 32618513 Free PMC article.

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