Robertson AAB - Search Results

1

Synthesis and evaluation of NLRP3-inhibitory sulfonylurea [¹¹C]MCC950 in healthy animals.

Hill JR, Shao X, Massey NL, Stauff J, Sherman PS, Robertson AAB, Scott PJH. Hill JR, et al. Among authors: robertson aab. Bioorg Med Chem Lett. 2020 Jun 15;30(12):127186. doi: 10.1016/j.bmcl.2020.127186. Epub 2020 Apr 11. Bioorg Med Chem Lett. 2020. PMID: 32312583

2

Efficient synthesis of anacardic acid analogues and their antibacterial activities.

Mamidyala SK, Ramu S, Huang JX, Robertson AA, Cooper MA. Mamidyala SK, et al. Bioorg Med Chem Lett. 2013 Mar 15;23(6):1667-70. doi: 10.1016/j.bmcl.2013.01.074. Epub 2013 Jan 29. Bioorg Med Chem Lett. 2013. PMID: 23416004

3

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.

Coll RC, Robertson AA, Chae JJ, Higgins SC, Muñoz-Planillo R, Inserra MC, Vetter I, Dungan LS, Monks BG, Stutz A, Croker DE, Butler MS, Haneklaus M, Sutton CE, Núñez G, Latz E, Kastner DL, Mills KH, Masters SL, Schroder K, Cooper MA, O'Neill LA. Coll RC, et al. Nat Med. 2015 Mar;21(3):248-55. doi: 10.1038/nm.3806. Epub 2015 Feb 16. Nat Med. 2015. PMID: 25686105 Free PMC article.

4

The Endoplasmic Reticulum-Mitochondrion Tether ERMES Orchestrates Fungal Immune Evasion, Illuminating Inflammasome Responses to Hyphal Signals.

Tucey TM, Verma-Gaur J, Nguyen J, Hewitt VL, Lo TL, Shingu-Vazquez M, Robertson AA, Hill JR, Pettolino FA, Beddoe T, Cooper MA, Naderer T, Traven A. Tucey TM, et al. mSphere. 2016 May 25;1(3):e00074-16. doi: 10.1128/mSphere.00074-16. eCollection 2016 May-Jun. mSphere. 2016. PMID: 27303738 Free PMC article.

5

The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction.

van Hout GP, Bosch L, Ellenbroek GH, de Haan JJ, van Solinge WW, Cooper MA, Arslan F, de Jager SC, Robertson AA, Pasterkamp G, Hoefer IE. van Hout GP, et al. Eur Heart J. 2017 Mar 14;38(11):828-836. doi: 10.1093/eurheartj/ehw247. Eur Heart J. 2017. PMID: 27432019

6

Identification, Synthesis, and Biological Evaluation of the Major Human Metabolite of NLRP3 Inflammasome Inhibitor MCC950.

Salla M, Butler MS, Pelingon R, Kaeslin G, Croker DE, Reid JC, Baek JM, Bernhardt PV, Gillam EM, Cooper MA, Robertson AA. Salla M, et al. ACS Med Chem Lett. 2016 Sep 27;7(12):1034-1038. doi: 10.1021/acsmedchemlett.6b00198. eCollection 2016 Dec 8. ACS Med Chem Lett. 2016. PMID: 27994733 Free PMC article.

7

Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice.

Dempsey C, Rubio Araiz A, Bryson KJ, Finucane O, Larkin C, Mills EL, Robertson AAB, Cooper MA, O'Neill LAJ, Lynch MA. Dempsey C, et al. Among authors: robertson aab. Brain Behav Immun. 2017 Mar;61:306-316. doi: 10.1016/j.bbi.2016.12.014. Epub 2016 Dec 18. Brain Behav Immun. 2017. PMID: 28003153

8

Sulfonylureas as Concomitant Insulin Secretagogues and NLRP3 Inflammasome Inhibitors.

Hill JR, Coll RC, Sue N, Reid JC, Dou J, Holley CL, Pelingon R, Dickinson JB, Biden TJ, Schroder K, Cooper MA, Robertson AAB. Hill JR, et al. Among authors: robertson aab. ChemMedChem. 2017 Sep 7;12(17):1449-1457. doi: 10.1002/cmdc.201700270. Epub 2017 Aug 4. ChemMedChem. 2017. PMID: 28703484

9

Synthesis of deuterium-labelled analogues of NLRP3 inflammasome inhibitor MCC950.

Salla M, Butler MS, Massey NL, Reid JC, Cooper MA, Robertson AAB. Salla M, et al. Among authors: robertson aab. Bioorg Med Chem Lett. 2018 Feb 15;28(4):793-795. doi: 10.1016/j.bmcl.2017.12.054. Epub 2017 Dec 26. Bioorg Med Chem Lett. 2018. PMID: 29338910

10

Evidence against a role for NLRP3-driven islet inflammation in db/db mice.

Kammoun HL, Allen TL, Henstridge DC, Barre S, Coll RC, Lancaster GI, Cron L, Reibe S, Chan JY, Bensellam M, Laybutt DR, Butler MS, Robertson AAB, O'Neill LA, Cooper MA, Febbraio MA. Kammoun HL, et al. Among authors: robertson aab. Mol Metab. 2018 Apr;10:66-73. doi: 10.1016/j.molmet.2018.02.001. Epub 2018 Feb 7. Mol Metab. 2018. PMID: 29478918 Free PMC article.

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