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APOBEC-Induced Mutagenesis in Cancer.
Mertz TM, Collins CD, Dennis M, Coxon M, Roberts SA. Mertz TM, et al. Among authors: roberts sa. Annu Rev Genet. 2022 Nov 30;56:229-252. doi: 10.1146/annurev-genet-072920-035840. Epub 2022 Aug 26. Annu Rev Genet. 2022. PMID: 36028227 Review.
The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway.
Rosenbaum JC, Bonilla B, Hengel SR, Mertz TM, Herken BW, Kazemier HG, Pressimone CA, Ratterman TC, MacNary E, De Magis A, Kwon Y, Godin SK, Van Houten B, Normolle DP, Sung P, Das SR, Paeschke K, Roberts SA, VanDemark AP, Bernstein KA. Rosenbaum JC, et al. Among authors: roberts sa. Nat Commun. 2019 Aug 5;10(1):3515. doi: 10.1038/s41467-019-11374-8. Nat Commun. 2019. PMID: 31383866 Free PMC article.
APOBEC3A is a prominent cytidine deaminase in breast cancer.
Cortez LM, Brown AL, Dennis MA, Collins CD, Brown AJ, Mitchell D, Mertz TM, Roberts SA. Cortez LM, et al. Among authors: roberts sa. PLoS Genet. 2019 Dec 16;15(12):e1008545. doi: 10.1371/journal.pgen.1008545. eCollection 2019 Dec. PLoS Genet. 2019. PMID: 31841499 Free PMC article.
An impaired ubiquitin-proteasome system increases APOBEC3A abundance.
Coxon M, Dennis MA, Dananberg A, Collins CD, Wilson HE, Meekma J, Savenkova MI, Ng D, Osbron CA, Mertz TM, Goodman AG, Duttke SH, Maciejowski J, Roberts SA. Coxon M, et al. Among authors: roberts sa. NAR Cancer. 2023 Dec 19;5(4):zcad058. doi: 10.1093/narcan/zcad058. eCollection 2023 Dec. NAR Cancer. 2023. PMID: 38155930 Free PMC article.
An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers.
Roberts SA, Lawrence MS, Klimczak LJ, Grimm SA, Fargo D, Stojanov P, Kiezun A, Kryukov GV, Carter SL, Saksena G, Harris S, Shah RR, Resnick MA, Getz G, Gordenin DA. Roberts SA, et al. Nat Genet. 2013 Sep;45(9):970-6. doi: 10.1038/ng.2702. Epub 2013 Jul 14. Nat Genet. 2013. PMID: 23852170 Free PMC article.
782 results