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Page 1
Genetic inhibitors of APOBEC3B-induced mutagenesis.
Mertz TM, Rice-Reynolds E, Nguyen L, Wood A, Cordero C, Bray N, Harcy V, Vyas RK, Mitchell D, Lobachev K, Roberts SA. Mertz TM, et al. Genome Res. 2023 Sep;33(9):1568-1581. doi: 10.1101/gr.277430.122. Epub 2023 Aug 2. Genome Res. 2023. PMID: 37532520 Free PMC article.
Combining these three metrics, we were able to establish a multifactorial signature of APOBEC-induced mutations specific to (1) failure to remove H3K56 acetylation, (2) defective CTF18-RFC complex function, and (3) defective HR-mediated bypass of APOBEC-induced lesions. .. …
Combining these three metrics, we were able to establish a multifactorial signature of APOBEC-induced mutations specific to (1) failure to r …
Genetic modifiers of APOBEC-induced mutagenesis.
Mertz TM, Rice-Reynolds E, Nguyen L, Wood A, Bray N, Mitchell D, Lobachev K, Roberts SA. Mertz TM, et al. bioRxiv [Preprint]. 2023 Apr 6:2023.04.05.535598. doi: 10.1101/2023.04.05.535598. bioRxiv. 2023. PMID: 37066362 Free PMC article. Preprint.
Combining these three metrics we were able to establish a multifactorial signature of APOBEC-induced mutations specific to (1) failure to remove H3K56 acetylation, which results in extremely high A3B-induced mutagenesis, (2) defective CTF18-RFC complex function, which resu …
Combining these three metrics we were able to establish a multifactorial signature of APOBEC-induced mutations specific to (1) failure to re …
[Urban geographic space and fruit and vegetable consumption: 2013 National Health Survey].
Augusto NA, Jaime PC, Loch MR. Augusto NA, et al. Cien Saude Colet. 2022 Apr;27(4):1491-1502. doi: 10.1590/1413-81232022274.00352021. Epub 2021 Jun 3. Cien Saude Colet. 2022. PMID: 35475829 Free article. Portuguese.
It involved a population-based and cross-sectional study using data from the 2013 National Health Survey, considering 60,202 adults 18 years old. The dependent variables were regular fruit consumption (RFC) and regular vegetable consumption (RVC). The independent variable …
It involved a population-based and cross-sectional study using data from the 2013 National Health Survey, considering 60,202 adults 18 years …
A novel CDK9 inhibitor increases the efficacy of venetoclax (ABT-199) in multiple models of hematologic malignancies.
Phillips DC, Jin S, Gregory GP, Zhang Q, Xue J, Zhao X, Chen J, Tong Y, Zhang H, Smith M, Tahir SK, Clark RF, Penning TD, Devlin JR, Shortt J, Hsi ED, Albert DH, Konopleva M, Johnstone RW, Leverson JD, Souers AJ. Phillips DC, et al. Leukemia. 2020 Jun;34(6):1646-1657. doi: 10.1038/s41375-019-0652-0. Epub 2019 Dec 11. Leukemia. 2020. PMID: 31827241 Free PMC article.
Efficacy and long-term toxicity of the rituximab-fludarabine-cyclophosphamide combination therapy in Waldenstrom's macroglobulinemia.
Souchet L, Levy V, Ouzegdouh M, Tamburini J, Delmer A, Dupuis J, Le Gouill S, Pégourié-Bandelier B, Tournilhac O, Boubaya M, Vargaftig J, Choquet S, Leblond V; FILO (French Innovative Leukemia Organization). Souchet L, et al. Am J Hematol. 2016 Aug;91(8):782-6. doi: 10.1002/ajh.24405. Epub 2016 Jun 3. Am J Hematol. 2016. PMID: 27135784 Free article.
We report the outcomes of 82 patients (median age 61 years) treated with the RFC combination. Twenty-five patients were treatment-naive. RFC was administered every 4 weeks, for a median of five cycles. ...The 3-year overall survival rate was 90%. Long-lasting cytope …
We report the outcomes of 82 patients (median age 61 years) treated with the RFC combination. Twenty-five patients were treatment-nai …
Derivation of a chronic reference concentration for decalin.
Stuchal LD, Weil RE, Roberts SM. Stuchal LD, et al. Regul Toxicol Pharmacol. 2013 Jun;66(1):38-46. doi: 10.1016/j.yrtph.2013.02.011. Epub 2013 Feb 28. Regul Toxicol Pharmacol. 2013. PMID: 23454102
A 2-year mouse inhalation study was chosen as the critical study for the derivation of the chronic RfC. Benchmark dose modeling was utilized to derive a point of departure for hepatic necrosis, syncytial alteration, eosinophilic focus, and erythrophagocytosis. A BMDL10 of …
A 2-year mouse inhalation study was chosen as the critical study for the derivation of the chronic RfC. Benchmark dose modeling was u …
Cohesin acetylation speeds the replication fork.
Terret ME, Sherwood R, Rahman S, Qin J, Jallepalli PV. Terret ME, et al. Nature. 2009 Nov 12;462(7270):231-4. doi: 10.1038/nature08550. Nature. 2009. PMID: 19907496 Free PMC article.
Through single-molecule analysis, we demonstrate that the replication factor C (RFC)-CTF18 clamp loader (RFC(CTF18)) controls the velocity, spacing and restart activity of replication forks in human cells and is required for robust acetylation of cohesin's SMC3 subu …
Through single-molecule analysis, we demonstrate that the replication factor C (RFC)-CTF18 clamp loader (RFC(CTF18)) controls …
Reduced folate carrier 80A-->G polymorphism, plasma folate, and risk of placental abruption.
Ananth CV, Peltier MR, Moore DF, Kinzler WL, Leclerc D, Rozen RR; New Jersey-Placental Abruption Study Investigators. Ananth CV, et al. Hum Genet. 2008 Sep;124(2):137-45. doi: 10.1007/s00439-008-0531-7. Epub 2008 Jul 16. Hum Genet. 2008. PMID: 18629538 Free PMC article.
Data were derived from the New Jersey-Placental Abruption Study--a multicenter, case-control study of placental abruption (2002-2007). Maternal DNA was assayed for the RFC-1 c.80A-->G polymorphism using a PCR-dependent diagnostic test. ...It is therefore not surprising …
Data were derived from the New Jersey-Placental Abruption Study--a multicenter, case-control study of placental abruption (2002-2007). Mater …
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