Genetic inhibitors of APOBEC3B-induced mutagenesis.
Mertz TM, Rice-Reynolds E, Nguyen L, Wood A, Cordero C, Bray N, Harcy V, Vyas RK, Mitchell D, Lobachev K, Roberts SA.
Mertz TM, et al.
Genome Res. 2023 Sep;33(9):1568-1581. doi: 10.1101/gr.277430.122. Epub 2023 Aug 2.
Genome Res. 2023.
PMID: 37532520
Free PMC article.
Combining these three metrics, we were able to establish a multifactorial signature of APOBEC-induced mutations specific to (1) failure to remove H3K56 acetylation, (2) defective CTF18-RFC complex function, and (3) defective HR-mediated bypass of APOBEC-induced lesions. .. …
Combining these three metrics, we were able to establish a multifactorial signature of APOBEC-induced mutations specific to (1) failure to r …