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VHL-deficiency leads to reductive stress in renal cells.
Vellama H, Eskla KL, Eichelmann H, Hüva A, Tennant DA, Thakker A, Roberts J, Jagomäe T, Porosk R, Laisk A, Oja V, Rämma H, Volke V, Vasar E, Luuk H. Vellama H, et al. Among authors: roberts j. Free Radic Biol Med. 2023 Nov 1;208:1-12. doi: 10.1016/j.freeradbiomed.2023.07.029. Epub 2023 Jul 26. Free Radic Biol Med. 2023. PMID: 37506952 Free PMC article.
Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate.
Goncalves J, Moog S, Morin A, Gentric G, Müller S, Morrell AP, Kluckova K, Stewart TJ, Andoniadou CL, Lussey-Lepoutre C, Bénit P, Thakker A, Vettore L, Roberts J, Rodriguez R, Mechta-Grigoriou F, Gimenez-Roqueplo AP, Letouzé E, Tennant DA, Favier J. Goncalves J, et al. Among authors: roberts j. Cancer Res. 2021 Jul 1;81(13):3480-3494. doi: 10.1158/0008-5472.CAN-20-2936. Epub 2021 Jun 14. Cancer Res. 2021. PMID: 34127497 Free article.
Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions.
Westbrook RL, Bridges E, Roberts J, Escribano-Gonzalez C, Eales KL, Vettore LA, Walker PD, Vera-Siguenza E, Rana H, Cuozzo F, Eskla KL, Vellama H, Shaaban A, Nixon C, Luuk H, Lavery GG, Hodson DJ, Harris AL, Tennant DA. Westbrook RL, et al. Among authors: roberts j. Cell Rep. 2022 Feb 1;38(5):110320. doi: 10.1016/j.celrep.2022.110320. Cell Rep. 2022. PMID: 35108535 Free PMC article.
Restored biosynthetic pathways induced by MSCs serve as rescue mechanism in leukemia cells after L-asparaginase therapy.
Alquezar-Artieda N, Kuzilkova D, Roberts J, Hlozkova K, Pecinova A, Pecina P, Zwyrtkova M, Potuckova E, Kavan D, Hermanova I, Zaliova M, Novak P, Mracek T, Sramkova L, Tennant DA, Trka J, Starkova J. Alquezar-Artieda N, et al. Among authors: roberts j. Blood Adv. 2023 May 23;7(10):2228-2236. doi: 10.1182/bloodadvances.2021006431. Blood Adv. 2023. PMID: 36399517 Free PMC article.
LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic β cells.
Cuozzo F, Viloria K, Shilleh AH, Nasteska D, Frazer-Morris C, Tong J, Jiao Z, Boufersaoui A, Marzullo B, Rosoff DB, Smith HR, Bonner C, Kerr-Conte J, Pattou F, Nano R, Piemonti L, Johnson PRV, Spiers R, Roberts J, Lavery GG, Clark A, Ceresa CDL, Ray DW, Hodson L, Davies AP, Rutter GA, Oshima M, Scharfmann R, Merrins MJ, Akerman I, Tennant DA, Ludwig C, Hodson DJ. Cuozzo F, et al. Among authors: roberts j. Cell Rep. 2024 Apr 23;43(4):114047. doi: 10.1016/j.celrep.2024.114047. Epub 2024 Apr 11. Cell Rep. 2024. PMID: 38607916 Free article.
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