Roberge JY - Search Results

1

Acylpyrazoline-Based Third-Generation Selective Antichlamydial Compounds with Enhanced Potency.

Lu B, Qiao Q, Park ER, Wang Y, Gilleran JA, Pan M, Pilch DS, Wu X, Roberge JY, Fan H. Lu B, et al. Among authors: roberge jy. ACS Omega. 2023 Feb 8;8(7):6597-6607. doi: 10.1021/acsomega.2c06992. eCollection 2023 Feb 21. ACS Omega. 2023. PMID: 36844602 Free PMC article.

2

Design, synthesis, and biological evaluation of deuterated C-aryl glycoside as a potent and long-acting renal sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes.

Xu G, Lv B, Roberge JY, Xu B, Du J, Dong J, Chen Y, Peng K, Zhang L, Tang X, Feng Y, Xu M, Fu W, Zhang W, Zhu L, Deng Z, Sheng Z, Welihinda A, Sun X. Xu G, et al. Among authors: roberge jy. J Med Chem. 2014 Feb 27;57(4):1236-51. doi: 10.1021/jm401780b. Epub 2014 Feb 12. J Med Chem. 2014. PMID: 24456245

3

EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats.

Zhang W, Welihinda A, Mechanic J, Ding H, Zhu L, Lu Y, Deng Z, Sheng Z, Lv B, Chen Y, Roberge JY, Seed B, Wang YX. Zhang W, et al. Among authors: roberge jy. Pharmacol Res. 2011 Apr;63(4):284-93. doi: 10.1016/j.phrs.2011.01.001. Epub 2011 Jan 5. Pharmacol Res. 2011. PMID: 21215314

4

Design and synthesis of a G-protein-coupled receptor antagonist library of aryloxyalkanolamines using a polymer-supported acyclic acetal linker.

Roberge JY, Harikrishnan LS, Kamau MG, Ruan Z, Van Kirk K, Liu Y, Cooper CB, Poss MA, Dickson JK Jr, Gavai AV, Chao ST, Leith LW, Bednarz MS, Mathur A, Kakarla R, Schnur DM, Vaz R, Lawrence RM. Roberge JY, et al. J Comb Chem. 2009 Jan-Feb;11(1):72-82. doi: 10.1021/cc800051u. J Comb Chem. 2009. PMID: 19086798

5

Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y1 antagonists.

Chao H, Turdi H, Herpin TF, Roberge JY, Liu Y, Schnur DM, Poss MA, Rehfuss R, Hua J, Wu Q, Price LA, Abell LM, Schumacher WA, Bostwick JS, Steinbacher TE, Stewart AB, Ogletree ML, Huang CS, Chang M, Cacace AM, Arcuri MJ, Celani D, Wexler RR, Lawrence RM. Chao H, et al. Among authors: roberge jy. J Med Chem. 2013 Feb 28;56(4):1704-14. doi: 10.1021/jm301708u. Epub 2013 Feb 18. J Med Chem. 2013. PMID: 23368907

6

Discovery of novel 1-arylmethyl pyrrolidin-2-yl ethanol amines as calcium-sensing receptor antagonists.

Gavai AV, Vaz RJ, Mikkilineni AB, Roberge JY, Liu Y, Lawrence RM, Corte JR, Yang W, Bednarz M, Dickson JK Jr, Ma Z, Seethala R, Feyen JH. Gavai AV, et al. Among authors: roberge jy. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5478-82. doi: 10.1016/j.bmcl.2005.08.095. Epub 2005 Oct 10. Bioorg Med Chem Lett. 2005. PMID: 16216508

7

Discovery and initial SAR of imidazoquinoxalines as inhibitors of the Src-family kinase p56(Lck).

Chen P, Norris D, Iwanowicz EJ, Spergel SH, Lin J, Gu HH, Shen Z, Wityak J, Lin TA, Pang S, De Fex HF, Pitt S, Shen DR, Doweyko AM, Bassolino DA, Roberge JY, Poss MA, Chen BC, Schieven GL, Barrish JC. Chen P, et al. Among authors: roberge jy. Bioorg Med Chem Lett. 2002 May 20;12(10):1361-4. doi: 10.1016/s0960-894x(02)00191-9. Bioorg Med Chem Lett. 2002. PMID: 11992777

8

C-aryl glucosides substituted at the 4'-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.

Xu B, Feng Y, Cheng H, Song Y, Lv B, Wu Y, Wang C, Li S, Xu M, Du J, Peng K, Dong J, Zhang W, Zhang T, Zhu L, Ding H, Sheng Z, Welihinda A, Roberge JY, Seed B, Chen Y. Xu B, et al. Among authors: roberge jy. Bioorg Med Chem Lett. 2011 Aug 1;21(15):4465-70. doi: 10.1016/j.bmcl.2011.06.032. Epub 2011 Jun 16. Bioorg Med Chem Lett. 2011. PMID: 21737266

9

Identification of purine inhibitors of phosphodiesterase 7 (PDE7).

Pitts WJ, Vaccaro W, Huynh T, Leftheris K, Roberge JY, Barbosa J, Guo J, Brown B, Watson A, Donaldson K, Starling GC, Kiener PA, Poss MA, Dodd JH, Barrish JC. Pitts WJ, et al. Among authors: roberge jy. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2955-8. doi: 10.1016/j.bmcl.2004.03.021. Bioorg Med Chem Lett. 2004. PMID: 15125967

10

Discovery and structure-activity relationships of 2-benzylpyrrolidine-substituted aryloxypropanols as calcium-sensing receptor antagonists.

Yang W, Wang Y, Roberge JY, Ma Z, Liu Y, Michael Lawrence R, Rotella DP, Seethala R, Feyen JH, Dickson JK Jr. Yang W, et al. Among authors: roberge jy. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1225-8. doi: 10.1016/j.bmcl.2004.11.071. Bioorg Med Chem Lett. 2005. PMID: 15686947

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