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An update into the medicinal chemistry of translocator protein (TSPO) ligands.
Barresi E, Robello M, Costa B, Da Pozzo E, Baglini E, Salerno S, Da Settimo F, Martini C, Taliani S. Barresi E, et al. Among authors: robello m. Eur J Med Chem. 2021 Jan 1;209:112924. doi: 10.1016/j.ejmech.2020.112924. Epub 2020 Oct 14. Eur J Med Chem. 2021. PMID: 33081988 Review.
Lead Optimization of 2-Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitors for the Treatment of Gliomas.
Daniele S, La Pietra V, Barresi E, Di Maro S, Da Pozzo E, Robello M, La Motta C, Cosconati S, Taliani S, Marinelli L, Novellino E, Martini C, Da Settimo F. Daniele S, et al. Among authors: robello m. J Med Chem. 2016 May 26;59(10):4526-38. doi: 10.1021/acs.jmedchem.5b01767. Epub 2016 May 3. J Med Chem. 2016. PMID: 27050782
Toward PET imaging of A2B adenosine receptors: a carbon-11 labeled triazinobenzimidazole tracer: Synthesis and imaging of a new A2B PET tracer.
Petroni D, Giacomelli C, Taliani S, Barresi E, Robello M, Daniele S, Bartoli A, Burchielli S, Pardini S, Salvadori PA, Da Settimo F, Martini C, Trincavelli ML, Menichetti L. Petroni D, et al. Among authors: robello m. Nucl Med Biol. 2016 May;43(5):309-17. doi: 10.1016/j.nucmedbio.2016.02.005. Epub 2016 Feb 27. Nucl Med Biol. 2016. PMID: 27150034
The structure-activity profile of mercaptobenzamides' anti-HIV activity suggests that thermodynamics of metabolism is more important than binding affinity to the target.
Nikolayevskiy H, Robello M, Scerba MT, Pasternak EH, Saha M, Hartman TL, Buchholz CA, Buckheit RW Jr, Durell SR, Appella DH. Nikolayevskiy H, et al. Among authors: robello m. Eur J Med Chem. 2019 Sep 15;178:818-837. doi: 10.1016/j.ejmech.2019.06.020. Epub 2019 Jun 9. Eur J Med Chem. 2019. PMID: 31252286 Free PMC article.
104 results