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526 results

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Local senolysis in aged mice only partially replicates the benefits of systemic senolysis.
Farr JN, Saul D, Doolittle ML, Kaur J, Rowsey JL, Vos SJ, Froemming MN, Lagnado AB, Zhu Y, Weivoda M, Ikeno Y, Pignolo RJ, Niedernhofer LJ, Robbins PD, Jurk D, Passos JF, LeBrasseur NK, Tchkonia T, Kirkland JL, Monroe DG, Khosla S. Farr JN, et al. Among authors: robbins pd. J Clin Invest. 2023 Apr 17;133(8):e162519. doi: 10.1172/JCI162519. J Clin Invest. 2023. PMID: 36809340 Free PMC article.
In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers.
Samakkarnthai P, Saul D, Zhang L, Aversa Z, Doolittle ML, Sfeir JG, Kaur J, Atkinson EJ, Edwards JR, Russell GG, Pignolo RJ, Kirkland JL, Tchkonia T, Niedernhofer LJ, Monroe DG, Lebrasseur NK, Farr JN, Robbins PD, Khosla S. Samakkarnthai P, et al. Among authors: robbins pd. Aging (Albany NY). 2023 May 7;15(9):3331-3355. doi: 10.18632/aging.204701. Epub 2023 May 7. Aging (Albany NY). 2023. PMID: 37154858 Free PMC article.
Senotherapeutic drug treatment ameliorates chemotherapy-induced cachexia.
Englund DA, Jolliffe AM, Hanson GJ, Aversa Z, Zhang X, Jiang X, White TA, Zhang L, Monroe DG, Robbins PD, Niedernhofer LJ, Kamenecka TM, Khosla S, LeBrasseur NK. Englund DA, et al. Among authors: robbins pd. JCI Insight. 2024 Jan 23;9(2):e169512. doi: 10.1172/jci.insight.169512. JCI Insight. 2024. PMID: 38051584 Free PMC article.
Aging and chronic inflammation: highlights from a multidisciplinary workshop.
Saavedra D, Añé-Kourí AL, Barzilai N, Caruso C, Cho KH, Fontana L, Franceschi C, Frasca D, Ledón N, Niedernhofer LJ, Pereira K, Robbins PD, Silva A, Suarez GM, Berghe WV, von Zglinicki T, Pawelec G, Lage A. Saavedra D, et al. Among authors: robbins pd. Immun Ageing. 2023 Jun 8;20(1):25. doi: 10.1186/s12979-023-00352-w. Immun Ageing. 2023. PMID: 37291596 Free PMC article. Review.
A report on the International Society for Cell & Gene Therapy 2022 Scientific Signature Series, "Therapeutic advances with native and engineered human extracellular vesicles".
Toh WS, Yarani R, El Andaloussi S, Cho BS, Choi C, Corteling R, De Fougerolles A, Gimona M, Herz J, Khoury M, Robbins PD, Williams D, Weiss DJ, Rohde E, Giebel B, Lim SK. Toh WS, et al. Among authors: robbins pd. Cytotherapy. 2023 Aug;25(8):810-814. doi: 10.1016/j.jcyt.2023.02.009. Epub 2023 Mar 15. Cytotherapy. 2023. PMID: 36931996
Development of an IGF1R longevity variant mouse line using CRISPR/Cas9 genome editing.
Dou Y, Darvas M, Sharma K, Mathieu J, Morton J, Tan H, Soto-Palma C, Angelini LA, McGowan SJ, Niedernhofer LJ, Suh Y, Robbins PD, Barzilai N, Ladiges WC. Dou Y, et al. Among authors: robbins pd. Trends Biomed Res. 2020 Dec;3(1):121. doi: 10.15761/jtbr.1000121. Epub 2020 Oct 8. Trends Biomed Res. 2020. PMID: 37113577 Free PMC article.
Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used.
Harrison DE, Strong R, Reifsnyder P, Rosenthal N, Korstanje R, Fernandez E, Flurkey K, Ginsburg BC, Murrell MD, Javors MA, Lopez-Cruzan M, Nelson JF, Willcox BJ, Allsopp R, Watumull DM, Watumull DG, Cortopassi G, Kirkland JL, Tchkonia T, Choi YG, Yousefzadeh MJ, Robbins PD, Mitchell JR, Acar M, Sarnoski EA, Bene MR, Salmon A, Kumar N, Miller RA. Harrison DE, et al. Among authors: robbins pd. Geroscience. 2024 Feb;46(1):795-816. doi: 10.1007/s11357-023-01011-0. Epub 2023 Dec 2. Geroscience. 2024. PMID: 38041783 Free PMC article.
Osteoarthritis gene therapy in 2022.
Evans CH, Ghivizzani SC, Robbins PD. Evans CH, et al. Among authors: robbins pd. Curr Opin Rheumatol. 2023 Jan 1;35(1):37-43. doi: 10.1097/BOR.0000000000000918. Epub 2022 Nov 9. Curr Opin Rheumatol. 2023. PMID: 36508307 Free PMC article. Review.
Clinical validation of C12FDG as a marker associated with senescence and osteoarthritic phenotypes.
Hambright WS, Duke VR, Goff AD, Goff AW, Minas LT, Kloser H, Gao X, Huard C, Guo P, Lu A, Mitchell J, Mullen M, Su C, Tchkonia T, Espindola Netto JM, Robbins PD, Niedernhofer LJ, Kirkland JL, Bahney CS, Philippon M, Huard J. Hambright WS, et al. Among authors: robbins pd. Aging Cell. 2024 May 6:e14113. doi: 10.1111/acel.14113. Online ahead of print. Aging Cell. 2024. PMID: 38708778 Free article.
526 results