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NF-κB negatively impacts the myogenic potential of muscle-derived stem cells.
Lu A, Proto JD, Guo L, Tang Y, Lavasani M, Tilstra JS, Niedernhofer LJ, Wang B, Guttridge DC, Robbins PD, Huard J. Lu A, et al. Among authors: robbins pd. Mol Ther. 2012 Mar;20(3):661-8. doi: 10.1038/mt.2011.261. Epub 2011 Dec 13. Mol Ther. 2012. PMID: 22158056 Free PMC article.
mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging.
Takayama K, Kawakami Y, Lavasani M, Mu X, Cummins JH, Yurube T, Kuroda R, Kurosaka M, Fu FH, Robbins PD, Niedernhofer LJ, Huard J. Takayama K, et al. Among authors: robbins pd. J Orthop Res. 2017 Jul;35(7):1375-1382. doi: 10.1002/jor.23409. Epub 2016 Sep 22. J Orthop Res. 2017. PMID: 27572850 Free PMC article.
Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation.
Zhao J, Zhang L, Mu X, Doebelin C, Nguyen W, Wallace C, Reay DP, McGowan SJ, Corbo L, Clemens PR, Wilson GM, Watkins SC, Solt LA, Cameron MD, Huard J, Niedernhofer LJ, Kamenecka TM, Robbins PD. Zhao J, et al. Among authors: robbins pd. PLoS Biol. 2018 Jun 11;16(6):e2004663. doi: 10.1371/journal.pbio.2004663. eCollection 2018 Jun. PLoS Biol. 2018. PMID: 29889904 Free PMC article.
Rapamycin Rescues Age-Related Changes in Muscle-Derived Stem/Progenitor Cells from Progeroid Mice.
Kawakami Y, Hambright WS, Takayama K, Mu X, Lu A, Cummins JH, Matsumoto T, Yurube T, Kuroda R, Kurosaka M, Fu FH, Robbins PD, Niedernhofer LJ, Huard J. Kawakami Y, et al. Among authors: robbins pd. Mol Ther Methods Clin Dev. 2019 May 30;14:64-76. doi: 10.1016/j.omtm.2019.05.011. eCollection 2019 Sep 13. Mol Ther Methods Clin Dev. 2019. PMID: 31312666 Free PMC article.
ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging.
Zhao J, Zhang L, Lu A, Han Y, Colangelo D, Bukata C, Scibetta A, Yousefzadeh MJ, Li X, Gurkar AU, McGowan SJ, Angelini L, O'Kelly R, Li H, Corbo L, Sano T, Nick H, Pola E, Pilla SPS, Ladiges WC, Vo N, Huard J, Niedernhofer LJ, Robbins PD. Zhao J, et al. Among authors: robbins pd. Aging (Albany NY). 2020 Mar 22;12(6):4688-4710. doi: 10.18632/aging.102863. Epub 2020 Mar 22. Aging (Albany NY). 2020. PMID: 32201398 Free PMC article.
526 results