Rob Leurs - Search Results

Year	Number of Results
2002	9
2003	11
2004	15
2005	19
2006	14
2007	14
2008	14
2009	17
2010	16
2011	21
2012	23
2013	12
2014	5
2015	10
2016	12
2017	7
2018	11
2019	19
2020	10
2021	9
2022	8
2023	11
2024	7

1

Synthesis and Pharmacological Characterization of New Photocaged Agonists for Histamine H₃ and H₄ Receptors.

Zheng Y, Gao M, Wijtmans M, Vischer HF, Leurs R. Zheng Y, et al. Among authors: leurs r. Pharmaceuticals (Basel). 2024 Apr 21;17(4):536. doi: 10.3390/ph17040536. Pharmaceuticals (Basel). 2024. PMID: 38675496 Free PMC article.

2

Structural basis of ligand recognition and design of antihistamines targeting histamine H₄ receptor.

Xia R, Shi S, Xu Z, Vischer HF, Windhorst AD, Qian Y, Duan Y, Liang J, Chen K, Zhang A, Guo C, Leurs R, He Y. Xia R, et al. Among authors: leurs r. Nat Commun. 2024 Mar 20;15(1):2493. doi: 10.1038/s41467-024-46840-5. Nat Commun. 2024. PMID: 38509098 Free PMC article.

3

Pharmacological characterization of seven human histamine H₃ receptor isoforms.

Gao M, Dekker ME, Leurs R, Vischer HF. Gao M, et al. Among authors: leurs r. Eur J Pharmacol. 2024 Apr 5;968:176450. doi: 10.1016/j.ejphar.2024.176450. Epub 2024 Feb 21. Eur J Pharmacol. 2024. PMID: 38387718 Free article.

4

Pharmacological Characterization and Radiolabeling of VUF15485, a High-Affinity Small-Molecule Agonist for the Atypical Chemokine Receptor ACKR3.

Zarca AM, Adlere I, Viciano CP, Arimont-Segura M, Meyrath M, Simon IA, Bebelman JP, Laan D, Custers HGJ, Janssen E, Versteegh KL, Buzink MCML, Nesheva DN, Bosma R, de Esch IJP, Vischer HF, Wijtmans M, Szpakowska M, Chevigné A, Hoffmann C, de Graaf C, Zarzycka BA, Windhorst AD, Smit MJ, Leurs R. Zarca AM, et al. Among authors: leurs r. Mol Pharmacol. 2024 Mar 14;105(4):301-312. doi: 10.1124/molpharm.123.000835. Mol Pharmacol. 2024. PMID: 38346795

5

Lead Optimization of the 5-Phenylpyrazolopyrimidinone NPD-2975 toward Compounds with Improved Antitrypanosomal Efficacy.

Zheng Y, van den Kerkhof M, Ibrahim M, De Esch IJP, Maes L, Sterk GJ, Caljon G, Leurs R. Zheng Y, et al. Among authors: leurs r. J Med Chem. 2024 Feb 22;67(4):2849-2863. doi: 10.1021/acs.jmedchem.3c01976. Epub 2024 Feb 8. J Med Chem. 2024. PMID: 38330051 Free PMC article.

6

Small Molecule Fluorescent Ligands for the Atypical Chemokine Receptor 3 (ACKR3).

Dekkers S, Comez D, Karsai N, Arimont-Segura M, Canals M, Caspar B, de Graaf C, Kilpatrick LE, Leurs R, Kellam B, Hill SJ, Briddon SJ, Stocks MJ. Dekkers S, et al. Among authors: leurs r. ACS Med Chem Lett. 2023 Dec 8;15(1):143-148. doi: 10.1021/acsmedchemlett.3c00469. eCollection 2024 Jan 11. ACS Med Chem Lett. 2023. PMID: 38229752 Free PMC article.

7

Ligand-directed biased agonism at human histamine H₃ receptor isoforms across Gα_i/o- and β-arrestin2-mediated pathways.

Rahman SN, Imhaouran F, Leurs R, Christopoulos A, Valant C, Langmead CJ. Rahman SN, et al. Among authors: leurs r. Biochem Pharmacol. 2023 Dec 28:115988. doi: 10.1016/j.bcp.2023.115988. Online ahead of print. Biochem Pharmacol. 2023. PMID: 38159685 Free article.

8

Pharmacological Characterization of the Zebrafish (Danio Rerio) Histamine H₁ Receptor Reveals the Involvement of the Second Extracellular Loop in the Binding of Histamine.

McNaught-Flores DA, Kooistra AJ, Chen YC, Arias-Montano JA, Panula P, Leurs R. McNaught-Flores DA, et al. Among authors: leurs r. Mol Pharmacol. 2024 Jan 10;105(2):84-96. doi: 10.1124/molpharm.123.000741. Mol Pharmacol. 2024. PMID: 37977823

9

PSW-Designer: An Open-Source Computational Platform for the Design and Virtual Screening of Photopharmacological Ligands.

Simon IA, Homan EJ, Wijtmans M, Sundström M, Leurs R, De Esch IJP, Zarzycka BA. Simon IA, et al. Among authors: leurs r. J Chem Inf Model. 2023 Nov 13;63(21):6696-6705. doi: 10.1021/acs.jcim.3c01050. Epub 2023 Oct 13. J Chem Inf Model. 2023. PMID: 37831965 Free PMC article.

10

Predicting the target landscape of kinase inhibitors using 3D convolutional neural networks.

Kanev GK, Zhang Y, Kooistra AJ, Bender A, Leurs R, Bailey D, Würdinger T, de Graaf C, de Esch IJP, Westerman BA. Kanev GK, et al. Among authors: leurs r. PLoS Comput Biol. 2023 Sep 5;19(9):e1011301. doi: 10.1371/journal.pcbi.1011301. eCollection 2023 Sep. PLoS Comput Biol. 2023. PMID: 37669273 Free PMC article.

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