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SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage.
Rizzo A, Iachettini S, Salvati E, Zizza P, Maresca C, D'Angelo C, Benarroch-Popivker D, Capolupo A, Del Gaudio F, Cosconati S, Di Maro S, Merlino F, Novellino E, Amoreo CA, Mottolese M, Sperduti I, Gilson E, Biroccio A. Rizzo A, et al. Nucleic Acids Res. 2017 Feb 28;45(4):1820-1834. doi: 10.1093/nar/gkw1202. Nucleic Acids Res. 2017. PMID: 27923994 Free PMC article.
Biological activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration.
Leonetti C, Amodei S, D'Angelo C, Rizzo A, Benassi B, Antonelli A, Elli R, Stevens MF, D'Incalci M, Zupi G, Biroccio A. Leonetti C, et al. Among authors: rizzo a. Mol Pharmacol. 2004 Nov;66(5):1138-46. doi: 10.1124/mol.104.001537. Epub 2004 Aug 10. Mol Pharmacol. 2004. PMID: 15304549
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect.
Salvati E, Leonetti C, Rizzo A, Scarsella M, Mottolese M, Galati R, Sperduti I, Stevens MF, D'Incalci M, Blasco M, Chiorino G, Bauwens S, Horard B, Gilson E, Stoppacciaro A, Zupi G, Biroccio A. Salvati E, et al. Among authors: rizzo a. J Clin Invest. 2007 Nov;117(11):3236-47. doi: 10.1172/JCI32461. J Clin Invest. 2007. PMID: 17932567 Free PMC article.
Inhibition of PARP activity by PJ-34 leads to growth impairment and cell death associated with aberrant mitotic pattern and nucleolar actin accumulation in M14 melanoma cell line.
Chevanne M, Zampieri M, Caldini R, Rizzo A, Ciccarone F, Catizone A, D'Angelo C, Guastafierro T, Biroccio A, Reale A, Zupi G, Caiafa P. Chevanne M, et al. Among authors: rizzo a. J Cell Physiol. 2010 Feb;222(2):401-10. doi: 10.1002/jcp.21964. J Cell Physiol. 2010. PMID: 19890834
TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage.
Ye J, Lenain C, Bauwens S, Rizzo A, Saint-Léger A, Poulet A, Benarroch D, Magdinier F, Morere J, Amiard S, Verhoeyen E, Britton S, Calsou P, Salles B, Bizard A, Nadal M, Salvati E, Sabatier L, Wu Y, Biroccio A, Londoño-Vallejo A, Giraud-Panis MJ, Gilson E. Ye J, et al. Among authors: rizzo a. Cell. 2010 Jul 23;142(2):230-42. doi: 10.1016/j.cell.2010.05.032. Cell. 2010. PMID: 20655466 Free article.
1,903 results