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Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases.
Barajas JF, Shakya G, Moreno G, Rivera H Jr, Jackson DR, Topper CL, Vagstad AL, La Clair JJ, Townsend CA, Burkart MD, Tsai SC. Barajas JF, et al. Among authors: rivera h jr. Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4142-E4148. doi: 10.1073/pnas.1609001114. Epub 2017 May 8. Proc Natl Acad Sci U S A. 2017. PMID: 28484029 Free PMC article.
An unusual intramolecular trans-amidation.
Rivera H Jr, Dhar S, La Clair JJ, Tsai SC, Burkart MD. Rivera H Jr, et al. Tetrahedron. 2016 Jun 23;72(25):3605-3608. doi: 10.1016/j.tet.2016.01.062. Tetrahedron. 2016. PMID: 27346894 Free PMC article.
Azithromycin Synergizes with Cationic Antimicrobial Peptides to Exert Bactericidal and Therapeutic Activity Against Highly Multidrug-Resistant Gram-Negative Bacterial Pathogens.
Lin L, Nonejuie P, Munguia J, Hollands A, Olson J, Dam Q, Kumaraswamy M, Rivera H Jr, Corriden R, Rohde M, Hensler ME, Burkart MD, Pogliano J, Sakoulas G, Nizet V. Lin L, et al. Among authors: rivera h jr. EBioMedicine. 2015 Jun 10;2(7):690-8. doi: 10.1016/j.ebiom.2015.05.021. eCollection 2015 Jul. EBioMedicine. 2015. PMID: 26288841 Free PMC article.
Modeling linear and cyclic PKS intermediates through atom replacement.
Shakya G, Rivera H Jr, Lee DJ, Jaremko MJ, La Clair JJ, Fox DT, Haushalter RW, Schaub AJ, Bruegger J, Barajas JF, White AR, Kaur P, Gwozdziowski ER, Wong F, Tsai SC, Burkart MD. Shakya G, et al. Among authors: rivera h jr. J Am Chem Soc. 2014 Dec 3;136(48):16792-9. doi: 10.1021/ja5064857. Epub 2014 Nov 19. J Am Chem Soc. 2014. PMID: 25406716 Free PMC article.