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Systematic assessment of process analytical technologies for biologics.
Biotechnol Bioeng. 2022 Feb;119(2):423-434. doi: 10.1002/bit.27990. Epub 2021 Dec 13.
Biotechnol Bioeng. 2022.
PMID: 34778948
Tuning monoclonal antibody galactosylation using Raman spectroscopy-controlled lactic acid feeding.
W Eyster T, Talwar S, Fernandez J, Foster S, Hayes J, Allen R, Reidinger S, Wan B, Ji X, Aon J, Patel P, Ritz DB.
W Eyster T, et al. Among authors: ritz db.
Biotechnol Prog. 2021 Jan;37(1):e3085. doi: 10.1002/btpr.3085. Epub 2020 Oct 10.
Biotechnol Prog. 2021.
PMID: 32975043
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Exometabolome profiling reveals activation of the carnitine buffering pathway in fed-batch cultures of CHO cells co-fed with glucose and lactic acid.
Vappiani J, Eyster T, Orzechowski K, Ritz D, Patel P, Sévin D, Aon J.
Vappiani J, et al.
Biotechnol Prog. 2021 Nov;37(6):e3198. doi: 10.1002/btpr.3198. Epub 2021 Aug 10.
Biotechnol Prog. 2021.
PMID: 34328709
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Simultaneous Monitoring and Comparison of Multiple Product Quality Attributes for Cell Culture Processes at Different Scales Using a LC/MS/MS Based Multi-Attribute Method.
Liu Y, Fernandez J, Pu Z, Zhang H, Cao L, Aguilar I, Ritz D, Luo R, Read A, Laures A, Lan K, Ubiera A, Smith A, Patel P, Liu A.
Liu Y, et al.
J Pharm Sci. 2020 Nov;109(11):3319-3329. doi: 10.1016/j.xphs.2020.07.029. Epub 2020 Aug 3.
J Pharm Sci. 2020.
PMID: 32758544
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A Fully Integrated Online Platform For Real Time Monitoring Of Multiple Product Quality Attributes In Biopharmaceutical Processes For Monoclonal Antibody Therapeutics.
Liu Y, Zhang C, Chen J, Fernandez J, Vellala P, Kulkarni TA, Aguilar I, Ritz D, Lan K, Patel P, Liu A.
Liu Y, et al.
J Pharm Sci. 2022 Feb;111(2):358-367. doi: 10.1016/j.xphs.2021.09.011. Epub 2021 Sep 14.
J Pharm Sci. 2022.
PMID: 34534574
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Efficient optimization of time-varying inputs in a fed-batch cell culture process using design of dynamic experiments.
Luo Y, Stanton DA, Sharp RC, Parrillo AJ, Morgan KT, Ritz DB, Talwar S.
Luo Y, et al. Among authors: ritz db.
Biotechnol Prog. 2023 Nov-Dec;39(6):e3380. doi: 10.1002/btpr.3380. Epub 2023 Aug 2.
Biotechnol Prog. 2023.
PMID: 37531362
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