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Intravenous delivery of GS-441524 is efficacious in the African green monkey model of SARS-CoV-2 infection.
Antiviral Res. 2022 Jul;203:105329. doi: 10.1016/j.antiviral.2022.105329. Epub 2022 May 5.
Antiviral Res. 2022.
PMID: 35525335
Free PMC article.
Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants.
Pitts J, Li J, Perry JK, Du Pont V, Riola N, Rodriguez L, Lu X, Kurhade C, Xie X, Camus G, Manhas S, Martin R, Shi PY, Cihlar T, Porter DP, Mo H, Maiorova E, Bilello JP.
Pitts J, et al. Among authors: riola n.
Antimicrob Agents Chemother. 2022 Jun 21;66(6):e0022222. doi: 10.1128/aac.00222-22. Epub 2022 May 9.
Antimicrob Agents Chemother. 2022.
PMID: 35532238
Free PMC article.
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In Vitro Selection of Remdesivir-Resistant SARS-CoV-2 Demonstrates High Barrier to Resistance.
Checkmahomed L, Carbonneau J, Du Pont V, Riola NC, Perry JK, Li J, Paré B, Simpson SM, Smith MA, Porter DP, Boivin G.
Checkmahomed L, et al. Among authors: riola nc.
Antimicrob Agents Chemother. 2022 Jul 19;66(7):e0019822. doi: 10.1128/aac.00198-22. Epub 2022 Jun 16.
Antimicrob Agents Chemother. 2022.
PMID: 35708323
Free PMC article.
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Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys.
Mackman RL, Kalla RV, Babusis D, Pitts J, Barrett KT, Chun K, Du Pont V, Rodriguez L, Moshiri J, Xu Y, Lee M, Lee G, Bleier B, Nguyen AQ, O'Keefe BM, Ambrosi A, Cook M, Yu J, Dempah KE, Bunyan E, Riola NC, Lu X, Liu R, Davie A, Hsiang TY, Dearing J, Vermillion M, Gale M Jr, Niedziela-Majka A, Feng JY, Hedskog C, Bilello JP, Subramanian R, Cihlar T.
Mackman RL, et al. Among authors: riola nc.
J Med Chem. 2023 Sep 14;66(17):11701-11717. doi: 10.1021/acs.jmedchem.3c00750. Epub 2023 Aug 19.
J Med Chem. 2023.
PMID: 37596939
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Looking Back and Marching Forward: New Features in 2022.
Riola NP, Madden LE, Silverman ED.
Riola NP, et al.
J Rheumatol. 2022 Mar;49(3):237-238. doi: 10.3899/jrheum.211412.
J Rheumatol. 2022.
PMID: 35232831
No abstract available.
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