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Propensities of Fatty Acid-Modified ASOs: Self-Assembly vs Albumin Binding.
Kusznir EA, Hau JC, Portmann M, Reinhart AG, Falivene F, Bastien J, Worm J, Ross A, Lauer M, Ringler P, Sladojevich F, Huber S, Bleicher K, Keller M. Kusznir EA, et al. Among authors: ringler p. Bioconjug Chem. 2023 May 17;34(5):866-879. doi: 10.1021/acs.bioconjchem.3c00085. Epub 2023 May 5. Bioconjug Chem. 2023. PMID: 37145959
Prodrug-Activating Chain Exchange (PACE) converts targeted prodrug derivatives to functional bi- or multispecific antibodies.
Dickopf S, Buldun C, Vasic V, Georges G, Hage C, Mayer K, Forster M, Wessels U, Stubenrauch KG, Benz J, Ehler A, Lauer ME, Ringler P, Kobold S, Endres S, Klein C, Brinkmann U. Dickopf S, et al. Among authors: ringler p. Biol Chem. 2022 Jan 20;403(5-6):495-508. doi: 10.1515/hsz-2021-0401. Print 2022 Apr 26. Biol Chem. 2022. PMID: 35073465 Free PMC article.
Evaluation of bovine milk extracellular vesicles for the delivery of locked nucleic acid antisense oligonucleotides.
Grossen P, Portmann M, Koller E, Duschmalé M, Minz T, Sewing S, Pandya NJ, van Geijtenbeek SK, Ducret A, Kusznir EA, Huber S, Berrera M, Lauer ME, Ringler P, Nordbo B, Jensen ML, Sladojevich F, Jagasia R, Alex R, Gamboni R, Keller M. Grossen P, et al. Among authors: ringler p. Eur J Pharm Biopharm. 2021 Jan;158:198-210. doi: 10.1016/j.ejpb.2020.11.012. Epub 2020 Nov 26. Eur J Pharm Biopharm. 2021. PMID: 33248268
Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody.
Geiger M, Stubenrauch KG, Sam J, Richter WF, Jordan G, Eckmann J, Hage C, Nicolini V, Freimoser-Grundschober A, Ritter M, Lauer ME, Stahlberg H, Ringler P, Patel J, Sullivan E, Grau-Richards S, Endres S, Kobold S, Umaña P, Brünker P, Klein C. Geiger M, et al. Among authors: ringler p. Nat Commun. 2020 Jun 24;11(1):3196. doi: 10.1038/s41467-020-16838-w. Nat Commun. 2020. PMID: 32581215 Free PMC article.
The Contorsbody, an antibody format for agonism: Design, structure, and function.
Georges GJ, Dengl S, Bujotzek A, Hesse F, Fischer JAA, Gärtner A, Benz J, Lauer ME, Ringler P, Stahlberg H, Plath F, Brinkmann U, Imhof-Jung S. Georges GJ, et al. Among authors: ringler p. Comput Struct Biotechnol J. 2020 May 14;18:1210-1220. doi: 10.1016/j.csbj.2020.05.007. eCollection 2020. Comput Struct Biotechnol J. 2020. PMID: 32542107 Free PMC article.
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