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Advances in eicosanoid research, novel therapeutic implications.
Haeggström JZ, Rinaldo-Matthis A, Wheelock CE, Wetterholm A. Haeggström JZ, et al. Biochem Biophys Res Commun. 2010 May 21;396(1):135-9. doi: 10.1016/j.bbrc.2010.03.140. Biochem Biophys Res Commun. 2010. PMID: 20494126 Review.
Arginine 104 is a key catalytic residue in leukotriene C4 synthase.
Rinaldo-Matthis A, Wetterholm A, Martinez Molina D, Holm J, Niegowski D, Ohlson E, Nordlund P, Morgenstern R, Haeggström JZ. Rinaldo-Matthis A, et al. J Biol Chem. 2010 Dec 24;285(52):40771-6. doi: 10.1074/jbc.M110.105940. Epub 2010 Oct 27. J Biol Chem. 2010. PMID: 20980252 Free PMC article.
Product formation controlled by substrate dynamics in leukotriene A4 hydrolase.
Stsiapanava A, Tholander F, Kumar RB, Qureshi AA, Niegowski D, Hasan M, Thunnissen M, Haeggström JZ, Rinaldo-Matthis A. Stsiapanava A, et al. Biochim Biophys Acta. 2014 Feb;1844(2):439-46. doi: 10.1016/j.bbapap.2013.12.003. Epub 2013 Dec 11. Biochim Biophys Acta. 2014. PMID: 24333438
Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor.
Stsiapanava A, Olsson U, Wan M, Kleinschmidt T, Rutishauser D, Zubarev RA, Samuelsson B, Rinaldo-Matthis A, Haeggström JZ. Stsiapanava A, et al. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4227-32. doi: 10.1073/pnas.1402136111. Epub 2014 Mar 3. Proc Natl Acad Sci U S A. 2014. PMID: 24591641 Free PMC article.
33 results