Riggs LM - Search Results

1

Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms.

Zanos P, Moaddel R, Morris PJ, Riggs LM, Highland JN, Georgiou P, Pereira EFR, Albuquerque EX, Thomas CJ, Zarate CA Jr, Gould TD. Zanos P, et al. Among authors: riggs lm. Pharmacol Rev. 2018 Jul;70(3):621-660. doi: 10.1124/pr.117.015198. Pharmacol Rev. 2018. PMID: 29945898 Free PMC article. Review.

2

(2R,6R)-hydroxynorketamine rapidly potentiates hippocampal glutamatergic transmission through a synapse-specific presynaptic mechanism.

Riggs LM, Aracava Y, Zanos P, Fischell J, Albuquerque EX, Pereira EFR, Thompson SM, Gould TD. Riggs LM, et al. Neuropsychopharmacology. 2020 Jan;45(2):426-436. doi: 10.1038/s41386-019-0443-3. Epub 2019 Jun 19. Neuropsychopharmacology. 2020. PMID: 31216563 Free PMC article.

3

Ketamine and the Future of Rapid-Acting Antidepressants.

Riggs LM, Gould TD. Riggs LM, et al. Annu Rev Clin Psychol. 2021 May 7;17:207-231. doi: 10.1146/annurev-clinpsy-072120-014126. Epub 2021 Feb 9. Annu Rev Clin Psychol. 2021. PMID: 33561364 Free PMC article. Review.

4

Hydroxynorketamines: Pharmacology and Potential Therapeutic Applications.

Highland JN, Zanos P, Riggs LM, Georgiou P, Clark SM, Morris PJ, Moaddel R, Thomas CJ, Zarate CA Jr, Pereira EFR, Gould TD. Highland JN, et al. Among authors: riggs lm. Pharmacol Rev. 2021 Apr;73(2):763-791. doi: 10.1124/pharmrev.120.000149. Pharmacol Rev. 2021. PMID: 33674359 Free PMC article. Review.

5

(R,S)-ketamine and (2R,6R)-hydroxynorketamine differentially affect memory as a function of dosing frequency.

Riggs LM, An X, Pereira EFR, Gould TD. Riggs LM, et al. Transl Psychiatry. 2021 Nov 12;11(1):583. doi: 10.1038/s41398-021-01685-0. Transl Psychiatry. 2021. PMID: 34772915 Free PMC article.

6

Mechanisms of ketamine and its metabolites as antidepressants.

Hess EM, Riggs LM, Michaelides M, Gould TD. Hess EM, et al. Among authors: riggs lm. Biochem Pharmacol. 2022 Mar;197:114892. doi: 10.1016/j.bcp.2021.114892. Epub 2021 Dec 27. Biochem Pharmacol. 2022. PMID: 34968492 Free PMC article. Review.

7

Hydroxynorketamine Pharmacokinetics and Antidepressant Behavioral Effects of (2,6)- and (5R)-Methyl-(2R,6R)-hydroxynorketamines.

Highland JN, Morris PJ, Konrath KM, Riggs LM, Hagen NR, Zanos P, Powels CF, Moaddel R, Thomas CJ, Wang AQ, Gould TD. Highland JN, et al. Among authors: riggs lm. ACS Chem Neurosci. 2022 Feb 16;13(4):510-523. doi: 10.1021/acschemneuro.1c00761. Epub 2022 Feb 3. ACS Chem Neurosci. 2022. PMID: 35113535 Free PMC article.

8

Rare variants implicate NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorder.

Hasin N, Riggs LM, Shekhtman T, Ashworth J, Lease R, Oshone RT, Humphries EM, Badner JA, Thomson PA, Glahn DC, Craig DW, Edenberg HJ, Gershon ES, McMahon FJ, Nurnberger JI, Zandi PP, Kelsoe JR, Roach JC, Gould TD, Ament SA. Hasin N, et al. Among authors: riggs lm. Mol Psychiatry. 2022 Sep;27(9):3842-3856. doi: 10.1038/s41380-022-01609-4. Epub 2022 May 11. Mol Psychiatry. 2022. PMID: 35546635

9

(2R,6R)-hydroxynorketamine rapidly potentiates optically-evoked Schaffer collateral synaptic activity.

Riggs LM, Thompson SM, Gould TD. Riggs LM, et al. Neuropharmacology. 2022 Aug 15;214:109153. doi: 10.1016/j.neuropharm.2022.109153. Epub 2022 May 31. Neuropharmacology. 2022. PMID: 35661657 Free PMC article.

10

cAMP-dependent protein kinase signaling is required for (2R,6R)-hydroxynorketamine to potentiate hippocampal glutamatergic transmission.

Riggs LM, Pereira EFR, Thompson SM, Gould TD. Riggs LM, et al. J Neurophysiol. 2024 Jan 1;131(1):64-74. doi: 10.1152/jn.00326.2023. Epub 2023 Dec 5. J Neurophysiol. 2024. PMID: 38050689

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