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BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis.
Wilhelm SM, Carter C, Tang L, Wilkie D, McNabola A, Rong H, Chen C, Zhang X, Vincent P, McHugh M, Cao Y, Shujath J, Gawlak S, Eveleigh D, Rowley B, Liu L, Adnane L, Lynch M, Auclair D, Taylor I, Gedrich R, Voznesensky A, Riedl B, Post LE, Bollag G, Trail PA. Wilhelm SM, et al. Among authors: riedl b. Cancer Res. 2004 Oct 1;64(19):7099-109. doi: 10.1158/0008-5472.CAN-04-1443. Cancer Res. 2004. PMID: 15466206
Omega-carboxypyridyl substituted ureas as Raf kinase inhibitors: SAR of the amide substituent.
Khire UR, Bankston D, Barbosa J, Brittelli DR, Caringal Y, Carlson R, Dumas J, Gane T, Heald SL, Hibner B, Johnson JS, Katz ME, Kennure N, Kingery-Wood J, Lee W, Liu XG, Lowinger TB, McAlexander I, Monahan MK, Natero R, Renick J, Riedl B, Rong H, Sibley RN, Smith RA, Wolanin D. Khire UR, et al. Among authors: riedl b. Bioorg Med Chem Lett. 2004 Feb 9;14(3):783-6. doi: 10.1016/j.bmcl.2003.11.041. Bioorg Med Chem Lett. 2004. PMID: 14741289
Discovery of a new class of p38 kinase inhibitors.
Dumas J, Sibley R, Riedl B, Monahan MK, Lee W, Lowinger TB, Redman AM, Johnson JS, Kingery-Wood J, Scott WJ, Smith RA, Bobko M, Schoenleber R, Ranges GE, Housley TJ, Bhargava A, Wilhelm SM, Shrikhande A. Dumas J, et al. Among authors: riedl b. Bioorg Med Chem Lett. 2000 Sep 18;10(18):2047-50. doi: 10.1016/s0960-894x(00)00270-5. Bioorg Med Chem Lett. 2000. PMID: 10999467
1-Phenyl-5-pyrazolyl ureas: potent and selective p38 kinase inhibitors.
Dumas J, Hatoum-Mokdad H, Sibley R, Riedl B, Scott WJ, Monahan MK, Lowinger TB, Brennan C, Natero R, Turner T, Johnson JS, Schoenleber R, Bhargava A, Wilhelm SM, Housley TJ, Ranges GE, Shrikhande A. Dumas J, et al. Among authors: riedl b. Bioorg Med Chem Lett. 2000 Sep 18;10(18):2051-4. doi: 10.1016/s0960-894x(00)00272-9. Bioorg Med Chem Lett. 2000. PMID: 10999468
Combined tyrosine and serine/threonine kinase inhibition by sorafenib prevents progression of experimental pulmonary hypertension and myocardial remodeling.
Klein M, Schermuly RT, Ellinghaus P, Milting H, Riedl B, Nikolova S, Pullamsetti SS, Weissmann N, Dony E, Savai R, Ghofrani HA, Grimminger F, Busch AE, Schäfer S. Klein M, et al. Among authors: riedl b. Circulation. 2008 Nov 11;118(20):2081-90. doi: 10.1161/CIRCULATIONAHA.108.779751. Epub 2008 Oct 27. Circulation. 2008. PMID: 18955668
Adrenomedullin 2.0: Adjusting Key Levers for Metabolic Stability.
Schönauer R, Els-Heindl S, Fischer JP, Köbberling J, Riedl B, Beck-Sickinger AG. Schönauer R, et al. Among authors: riedl b. J Med Chem. 2016 Jun 23;59(12):5695-705. doi: 10.1021/acs.jmedchem.6b00126. Epub 2016 Jun 6. J Med Chem. 2016. PMID: 27166982
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