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Mitochondrial membrane lipidome defines yeast longevity.
Beach A, Richard VR, Leonov A, Burstein MT, Bourque SD, Koupaki O, Juneau M, Feldman R, Iouk T, Titorenko VI. Beach A, et al. Among authors: richard vr. Aging (Albany NY). 2013 Jul;5(7):551-74. doi: 10.18632/aging.100578. Aging (Albany NY). 2013. PMID: 23924582 Free PMC article.
Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes.
Goldberg AA, Richard VR, Kyryakov P, Bourque SD, Beach A, Burstein MT, Glebov A, Koupaki O, Boukh-Viner T, Gregg C, Juneau M, English AM, Thomas DY, Titorenko VI. Goldberg AA, et al. Among authors: richard vr. Aging (Albany NY). 2010 Jul;2(7):393-414. doi: 10.18632/aging.100168. Aging (Albany NY). 2010. PMID: 20622262 Free PMC article.
Macromitophagy is a longevity assurance process that in chronologically aging yeast limited in calorie supply sustains functional mitochondria and maintains cellular lipid homeostasis.
Richard VR, Leonov A, Beach A, Burstein MT, Koupaki O, Gomez-Perez A, Levy S, Pluska L, Mattie S, Rafesh R, Iouk T, Sheibani S, Greenwood M, Vali H, Titorenko VI. Richard VR, et al. Aging (Albany NY). 2013 Apr;5(4):234-69. doi: 10.18632/aging.100547. Aging (Albany NY). 2013. PMID: 23553280 Free PMC article.
Lithocholic bile acid accumulated in yeast mitochondria orchestrates a development of an anti-aging cellular pattern by causing age-related changes in cellular proteome.
Beach A, Richard VR, Bourque S, Boukh-Viner T, Kyryakov P, Gomez-Perez A, Arlia-Ciommo A, Feldman R, Leonov A, Piano A, Svistkova V, Titorenko VI. Beach A, et al. Among authors: richard vr. Cell Cycle. 2015;14(11):1643-56. doi: 10.1080/15384101.2015.1026493. Cell Cycle. 2015. PMID: 25839782 Free PMC article.
A novel function of lipid droplets in regulating longevity.
Goldberg AA, Bourque SD, Kyryakov P, Boukh-Viner T, Gregg C, Beach A, Burstein MT, Machkalyan G, Richard V, Rampersad S, Titorenko VI. Goldberg AA, et al. Biochem Soc Trans. 2009 Oct;37(Pt 5):1050-5. doi: 10.1042/BST0371050. Biochem Soc Trans. 2009. PMID: 19754450
Interspecies Chemical Signals Released into the Environment May Create Xenohormetic, Hormetic and Cytostatic Selective Forces that Drive the Ecosystemic Evolution of Longevity Regulation Mechanisms.
Burstein MT, Beach A, Richard VR, Koupaki O, Gomez-Perez A, Goldberg AA, Kyryakov P, Bourque SD, Glebov A, Titorenko VI. Burstein MT, et al. Among authors: richard vr. Dose Response. 2012;10(1):75-82. doi: 10.2203/dose-response.11-011.Titorenko. Epub 2011 Jul 27. Dose Response. 2012. PMID: 22423230 Free PMC article.
56 results