Richard B. Silverman - Search Results

Year	Number of Results
1996	1
1998	1
2002	4
2003	10
2004	10
2005	8
2006	10
2007	9
2008	5
2009	13
2010	17
2011	16
2012	21
2013	17
2014	18
2015	18
2016	6
2017	7
2018	7
2019	8
2020	8
2021	9
2022	7
2023	7
2024	4

1

Design, Synthesis, and Mechanistic Studies of (R)-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase.

Devitt AN, Vargas AL, Zhu W, Des Soye BJ, Butun FA, Alt T, Kaley N, Ferreira GM, Moran GR, Kelleher NL, Liu D, Silverman RB. Devitt AN, et al. Among authors: silverman rb. ACS Chem Biol. 2024 Apr 17. doi: 10.1021/acschembio.4c00022. Online ahead of print. ACS Chem Biol. 2024. PMID: 38630468

2

Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase.

Li H, Hardy CD, Reidl CT, Jing Q, Xue F, Cinelli M, Silverman RB, Poulos TL. Li H, et al. Among authors: silverman rb. Biochemistry. 2024 Mar 19;63(6):788-796. doi: 10.1021/acs.biochem.3c00601. Epub 2024 Feb 28. Biochemistry. 2024. PMID: 38417024 Free PMC article.

3

Target Identification of a Class of Pyrazolone Protein Aggregation Inhibitor Therapeutics for Amyotrophic Lateral Sclerosis.

Weerawarna PM, Schiefer IT, Soares P, Fox S, Morimoto RI, Melani RD, Kelleher NL, Luan CH, Silverman RB. Weerawarna PM, et al. Among authors: silverman rb. ACS Cent Sci. 2023 Dec 20;10(1):87-103. doi: 10.1021/acscentsci.3c00213. eCollection 2024 Jan 24. ACS Cent Sci. 2023. PMID: 38292603 Free PMC article.

4

From TgO/GABA-AT, GABA, and T-263 Mutant to Conception of Toxoplasma.

Lykins J, Moschitto MJ, Zhou Y, Filippova EV, Le HV, Tomita T, Fox BA, Bzik DJ, Su C, Rajagopala SV, Flores K, Spano F, Woods S, Roberts CW, Hua C, El Bissati K, Wheeler KM, Dovgin S, Muench SP, McPhillie M, Fishwick CWG, Anderson WF, Lee PJ, Hickman M, Weiss LM, Dubey JP, Lorenzi HA, Silverman RB, McLeod RL. Lykins J, et al. Among authors: silverman rb. iScience. 2023 Nov 16;27(1):108477. doi: 10.1016/j.isci.2023.108477. eCollection 2024 Jan 19. iScience. 2023. PMID: 38205261 Free PMC article.

5

Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors.

Vasu D, Do HT, Li H, Hardy CD, Awasthi A, Poulos TL, Silverman RB. Vasu D, et al. Among authors: silverman rb. J Med Chem. 2023 Jul 27;66(14):9934-9953. doi: 10.1021/acs.jmedchem.3c00782. Epub 2023 Jul 11. J Med Chem. 2023. PMID: 37433128

6

Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis.

Elmansy MF, Reidl CT, Rahaman M, Özdinler PH, Silverman RB. Elmansy MF, et al. Among authors: silverman rb. Med Res Rev. 2023 Nov;43(6):2260-2302. doi: 10.1002/med.21974. Epub 2023 May 26. Med Res Rev. 2023. PMID: 37243319 Review.

7

Improved synthesis and anticancer activity of a potent neuronal nitric oxide synthase inhibitor.

Vasu D, Reidl CT, Wang E, Yang S, Silverman RB. Vasu D, et al. Among authors: silverman rb. Bioorg Med Chem Lett. 2023 Jun 15;90:129329. doi: 10.1016/j.bmcl.2023.129329. Epub 2023 May 15. Bioorg Med Chem Lett. 2023. PMID: 37196870

8

Correction to "Rational Design, Synthesis, and Mechanism of (3S,4R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase".

Zhu W, Butrin A, Melani RD, Doubleday PF, Ferreira GM, Tavares MT, Habeeb Mohammad TS, Beaupre BA, Kelleher NL, Moran GR, Liu D, Silverman RB. Zhu W, et al. Among authors: silverman rb. J Am Chem Soc. 2023 May 3;145(17):9895-9896. doi: 10.1021/jacs.3c03364. Epub 2023 Apr 19. J Am Chem Soc. 2023. PMID: 37075548 No abstract available.

9

Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3S,4S)-3-Amino-4-fluorocyclopentenecarboxylic Acid.

Shen S, Butrin A, Beaupre BA, Ferreira GM, Doubleday PF, Grass DH, Zhu W, Kelleher NL, Moran GR, Liu D, Silverman RB. Shen S, et al. Among authors: silverman rb. Molecules. 2023 Jan 23;28(3):1133. doi: 10.3390/molecules28031133. Molecules. 2023. PMID: 36770800 Free PMC article.

10

2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors.

Vasu D, Li H, Hardy CD, Poulos TL, Silverman RB. Vasu D, et al. Among authors: silverman rb. Bioorg Med Chem. 2022 Sep 1;69:116878. doi: 10.1016/j.bmc.2022.116878. Epub 2022 Jun 11. Bioorg Med Chem. 2022. PMID: 35772285 Free PMC article.

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