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Defective Bile Acid Signaling Promotes Vascular Dysfunction, Supporting a Role for G-Protein Bile Acid Receptor 1/Farnesoid X Receptor Agonism and Statins in the Treatment of Nonalcoholic Fatty Liver Disease.
Marchianò S, Biagioli M, Bordoni M, Morretta E, Di Giorgio C, Vellecco V, Roselli R, Bellini R, Massa C, Cari L, Urbani G, Ricci P, Monti MC, Giordano A, Brancaleone V, Bucci M, Zampella A, Distrutti E, Cieri E, Cirino G, Fiorucci S. Marchianò S, et al. Among authors: ricci p. J Am Heart Assoc. 2023 Dec 5;12(23):e031241. doi: 10.1161/JAHA.123.031241. Epub 2023 Nov 23. J Am Heart Assoc. 2023. PMID: 37996988 Free PMC article.
Ursodeoxycholic acid is a GPBAR1 agonist and resets liver/intestinal FXR signaling in a model of diet-induced dysbiosis and NASH.
Carino A, Biagioli M, Marchianò S, Fiorucci C, Zampella A, Monti MC, Scarpelli P, Ricci P, Distrutti E, Fiorucci S. Carino A, et al. Among authors: ricci p. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct;1864(10):1422-1437. doi: 10.1016/j.bbalip.2019.07.006. Epub 2019 Jul 17. Biochim Biophys Acta Mol Cell Biol Lipids. 2019. PMID: 31325638
Opposite effects of the FXR agonist obeticholic acid on Mafg and Nrf2 mediate the development of acute liver injury in rodent models of cholestasis.
Carino A, Biagioli M, Marchianò S, Fiorucci C, Bordoni M, Roselli R, Di Giorgio C, Baldoni M, Ricci P, Monti MC, Morretta E, Zampella A, Distrutti E, Fiorucci S. Carino A, et al. Among authors: ricci p. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Sep;1865(9):158733. doi: 10.1016/j.bbalip.2020.158733. Epub 2020 May 1. Biochim Biophys Acta Mol Cell Biol Lipids. 2020. PMID: 32371093
Immunomodulatory functions of FXR.
Fiorucci S, Zampella A, Ricci P, Distrutti E, Biagioli M. Fiorucci S, et al. Among authors: ricci p. Mol Cell Endocrinol. 2022 Jul 1;551:111650. doi: 10.1016/j.mce.2022.111650. Epub 2022 Apr 25. Mol Cell Endocrinol. 2022. PMID: 35472625
The Aryl Hydrocarbon Receptor (AhR) Mediates the Counter-Regulatory Effects of Pelargonidins in Models of Inflammation and Metabolic Dysfunctions.
Biagioli M, Carino A, Fiorucci C, Annunziato G, Marchianò S, Bordoni M, Roselli R, Giorgio CD, Castiglione F, Ricci P, Bruno A, Faccini A, Distrutti E, Baldoni M, Costantino G, Fiorucci S. Biagioli M, et al. Among authors: ricci p. Nutrients. 2019 Aug 7;11(8):1820. doi: 10.3390/nu11081820. Nutrients. 2019. PMID: 31394746 Free PMC article.
874 results