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The toxin BjussuLAAO-II induces oxidative stress and DNA damage, upregulates the inflammatory cytokine genes TNF and IL6, and downregulates the apoptotic-related genes BAX, BCL2 and RELA in human Caco-2 cells.
Machado ART, Aissa AF, Ribeiro DL, Hernandes LC, Machado CS, Bianchi MLP, Sampaio SV, Antunes LMG. Machado ART, et al. Among authors: ribeiro dl. Int J Biol Macromol. 2018 Apr 1;109:212-219. doi: 10.1016/j.ijbiomac.2017.12.015. Epub 2017 Dec 6. Int J Biol Macromol. 2018. PMID: 29222016
CR-LAAO causes genotoxic damage in HepG2 tumor cells by oxidative stress.
Costa TR, Amstalden MK, Ribeiro DL, Menaldo DL, Sartim MA, Aissa AF, Antunes LMG, Sampaio SV. Costa TR, et al. Among authors: ribeiro dl. Toxicology. 2018 Jul 1;404-405:42-48. doi: 10.1016/j.tox.2018.05.005. Epub 2018 May 5. Toxicology. 2018. PMID: 29738841
Cytotoxic, genotoxic, and oxidative stress-inducing effect of an l-amino acid oxidase isolated from Bothrops jararacussu venom in a co-culture model of HepG2 and HUVEC cells.
Machado ART, Aissa AF, Ribeiro DL, Costa TR, Ferreira RS Jr, Sampaio SV, Antunes LMG. Machado ART, et al. Among authors: ribeiro dl. Int J Biol Macromol. 2019 Apr 15;127:425-432. doi: 10.1016/j.ijbiomac.2019.01.059. Epub 2019 Jan 15. Int J Biol Macromol. 2019. PMID: 30654040 Free article.
Synephrine and caffeine combination promotes cytotoxicity, DNA damage and transcriptional modulation of apoptosis-related genes in human HepG2 cells.
Leão TK, Ribeiro DL, Machado ART, Costa TR, Sampaio SV, Antunes LMG. Leão TK, et al. Among authors: ribeiro dl. Mutat Res Genet Toxicol Environ Mutagen. 2021 Aug-Sep;868-869:503375. doi: 10.1016/j.mrgentox.2021.503375. Epub 2021 Jul 9. Mutat Res Genet Toxicol Environ Mutagen. 2021. PMID: 34454690 Free article.
Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells.
Dos Santos PWDS, Machado ART, De Grandis RA, Ribeiro DL, Tuttis K, Morselli M, Aissa AF, Pellegrini M, Antunes LMG. Dos Santos PWDS, et al. Among authors: ribeiro dl. Food Chem Toxicol. 2020 Feb;136:111047. doi: 10.1016/j.fct.2019.111047. Epub 2019 Dec 12. Food Chem Toxicol. 2020. PMID: 31838189
88 results