Rhym LH - Search Results

1

Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNA.

Li B, Jiang AY, Raji I, Atyeo C, Raimondo TM, Gordon AGR, Rhym LH, Samad T, MacIsaac C, Witten J, Mughal H, Chicz TM, Xu Y, McNamara RP, Bhatia S, Alter G, Langer R, Anderson DG. Li B, et al. Among authors: rhym lh. Nat Biomed Eng. 2023 Sep 7. doi: 10.1038/s41551-023-01082-6. Online ahead of print. Nat Biomed Eng. 2023. PMID: 37679571

2

Peptide-encoding mRNA barcodes for the high-throughput in vivo screening of libraries of lipid nanoparticles for mRNA delivery.

Rhym LH, Manan RS, Koller A, Stephanie G, Anderson DG. Rhym LH, et al. Nat Biomed Eng. 2023 Jul;7(7):901-910. doi: 10.1038/s41551-023-01030-4. Epub 2023 May 1. Nat Biomed Eng. 2023. PMID: 37127709

3

Nanoscale delivery platforms for RNA therapeutics: Challenges and the current state of the art.

Rhym LH, Anderson DG. Rhym LH, et al. Med. 2022 Mar 11;3(3):167-187. doi: 10.1016/j.medj.2022.02.001. Med. 2022. PMID: 35590191 Free article. Review.

4

Adenine base editing in an adult mouse model of tyrosinaemia.

Song CQ, Jiang T, Richter M, Rhym LH, Koblan LW, Zafra MP, Schatoff EM, Doman JL, Cao Y, Dow LE, Zhu LJ, Anderson DG, Liu DR, Yin H, Xue W. Song CQ, et al. Among authors: rhym lh. Nat Biomed Eng. 2020 Jan;4(1):125-130. doi: 10.1038/s41551-019-0357-8. Epub 2019 Feb 25. Nat Biomed Eng. 2020. PMID: 31740768 Free PMC article.

5

Reduction of the therapeutic dose of silencing RNA by packaging it in extracellular vesicles via a pre-microRNA backbone.

Reshke R, Taylor JA, Savard A, Guo H, Rhym LH, Kowalski PS, Trung MT, Campbell C, Little W, Anderson DG, Gibbings D. Reshke R, et al. Among authors: rhym lh. Nat Biomed Eng. 2020 Jan;4(1):52-68. doi: 10.1038/s41551-019-0502-4. Epub 2020 Jan 14. Nat Biomed Eng. 2020. PMID: 31937944

6

Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing.

Yin H, Song CQ, Suresh S, Wu Q, Walsh S, Rhym LH, Mintzer E, Bolukbasi MF, Zhu LJ, Kauffman K, Mou H, Oberholzer A, Ding J, Kwan SY, Bogorad RL, Zatsepin T, Koteliansky V, Wolfe SA, Xue W, Langer R, Anderson DG. Yin H, et al. Among authors: rhym lh. Nat Biotechnol. 2017 Dec;35(12):1179-1187. doi: 10.1038/nbt.4005. Epub 2017 Nov 13. Nat Biotechnol. 2017. PMID: 29131148 Free PMC article.

7

Customizable Lipid Nanoparticle Materials for the Delivery of siRNAs and mRNAs.

Fenton OS, Kauffman KJ, McClellan RL, Kaczmarek JC, Zeng MD, Andresen JL, Rhym LH, Heartlein MW, DeRosa F, Anderson DG. Fenton OS, et al. Among authors: rhym lh. Angew Chem Int Ed Engl. 2018 Oct 8;57(41):13582-13586. doi: 10.1002/anie.201809056. Epub 2018 Sep 14. Angew Chem Int Ed Engl. 2018. PMID: 30112821 Free PMC article.

8

Systemic delivery of mRNA and DNA to the lung using polymer-lipid nanoparticles.

Kaczmarek JC, Patel AK, Rhym LH, Palmiero UC, Bhat B, Heartlein MW, DeRosa F, Anderson DG. Kaczmarek JC, et al. Among authors: rhym lh. Biomaterials. 2021 Aug;275:120966. doi: 10.1016/j.biomaterials.2021.120966. Epub 2021 Jun 10. Biomaterials. 2021. PMID: 34147715

9

Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope.

Jiang T, Henderson JM, Coote K, Cheng Y, Valley HC, Zhang XO, Wang Q, Rhym LH, Cao Y, Newby GA, Bihler H, Mense M, Weng Z, Anderson DG, McCaffrey AP, Liu DR, Xue W. Jiang T, et al. Among authors: rhym lh. Nat Commun. 2020 Apr 24;11(1):1979. doi: 10.1038/s41467-020-15892-8. Nat Commun. 2020. PMID: 32332735 Free PMC article.

10

Downregulation of the Arg/N-degron Pathway Sensitizes Cancer Cells to Chemotherapy In Vivo.

Leboeuf D, Abakumova T, Prikazchikova T, Rhym L, Anderson DG, Zatsepin TS, Piatkov KI. Leboeuf D, et al. Mol Ther. 2020 Apr 8;28(4):1092-1104. doi: 10.1016/j.ymthe.2020.01.021. Epub 2020 Jan 21. Mol Ther. 2020. PMID: 32087767 Free PMC article.

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