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A novel mouse AAV6 hACE2 transduction model of wild-type SARS-CoV-2 infection studied using synDNA immunogens.
Gary EN, Warner BM, Parzych EM, Griffin BD, Zhu X, Tailor N, Tursi NJ, Chan M, Purwar M, Vendramelli R, Choi J, Frost KL, Reeder S, Liaw K, Tello E, Ali AR, Yun K, Pei Y, Thomas SP, Rghei AD, Guilleman MM, Muthumani K, Smith T, Wootton SK, Patel A, Weiner DB, Kobasa D. Gary EN, et al. Among authors: rghei ad. iScience. 2021 Jul 23;24(7):102699. doi: 10.1016/j.isci.2021.102699. Epub 2021 Jun 8. iScience. 2021. PMID: 34124612 Free PMC article.
AAV Vectored Immunoprophylaxis for Filovirus Infections.
Rghei AD, van Lieshout LP, Santry LA, Guilleman MM, Thomas SP, Susta L, Karimi K, Bridle BW, Wootton SK. Rghei AD, et al. Trop Med Infect Dis. 2020 Nov 9;5(4):169. doi: 10.3390/tropicalmed5040169. Trop Med Infect Dis. 2020. PMID: 33182447 Free PMC article. Review.
Safety and Tolerability of the Adeno-Associated Virus Vector, AAV6.2FF, Expressing a Monoclonal Antibody in Murine and Ovine Animal Models.
Rghei AD, van Lieshout LP, McLeod BM, Pei Y, Lopes JA, Zielinska N, Baracuhy EM, Stevens BAY, Thomas SP, Yates JGE, Warner BM, Kobasa D, Fausther-Bovendo H, Kobinger GP, Karimi K, Thompson B, Bridle BW, Susta L, Wootton SK. Rghei AD, et al. Biomedicines. 2021 Sep 9;9(9):1186. doi: 10.3390/biomedicines9091186. Biomedicines. 2021. PMID: 34572372 Free PMC article.
AAV-monoclonal antibody expression protects mice from Ebola virus without impeding the endogenous antibody response to heterologous challenge.
van Lieshout LP, Rghei AD, Cao W, He S, Soule G, Zhu W, Thomas SP, Sorensen D, Frost K, Tierney K, Thompson B, Booth S, Safronetz D, Kulkarni RR, Bridle BW, Qiu X, Banadyga L, Wootton SK. van Lieshout LP, et al. Among authors: rghei ad. Mol Ther Methods Clin Dev. 2022 Aug 12;26:505-518. doi: 10.1016/j.omtm.2022.08.003. eCollection 2022 Sep 8. Mol Ther Methods Clin Dev. 2022. PMID: 36092367 Free PMC article.
Adeno-associated virus mediated expression of monoclonal antibody MR191 protects mice against Marburg virus and provides long-term expression in sheep.
Rghei AD, van Lieshout LP, Cao W, He S, Tierney K, Lopes JA, Zielinska N, Baracuhy EM, Campbell ESB, Minott JA, Guilleman MM, Hasson PC, Thompson B, Karimi K, Bridle BW, Susta L, Qiu X, Banadyga L, Wootton SK. Rghei AD, et al. Gene Ther. 2022 Sep 1. doi: 10.1038/s41434-022-00361-2. Online ahead of print. Gene Ther. 2022. PMID: 36050451
AAV-Vectored Expression of the Vascular Normalizing Agents 3TSR and Fc3TSR, and the Anti-Angiogenic Bevacizumab Extends Survival in a Murine Model of End-Stage Epithelial Ovarian Carcinoma.
Stegelmeier AA, Santry LA, Guilleman MM, Matuszewska K, Minott JA, Yates JGE, Stevens BAY, Thomas SP, Vanderkamp S, Hanada K, Pei Y, Rghei AD, van Vloten JP, Pereira M, Thompson B, Major PP, Petrik JJ, Bridle BW, Wootton SK. Stegelmeier AA, et al. Among authors: rghei ad. Biomedicines. 2022 Feb 2;10(2):362. doi: 10.3390/biomedicines10020362. Biomedicines. 2022. PMID: 35203573 Free PMC article.
Combining vanadyl sulfate with Newcastle disease virus potentiates rapid innate immune-mediated regression with curative potential in murine cancer models.
McAusland TM, van Vloten JP, Santry LA, Guilleman MM, Rghei AD, Ferreira EM, Ingrao JC, Arulanandam R, Major PP, Susta L, Karimi K, Diallo JS, Bridle BW, Wootton SK. McAusland TM, et al. Among authors: rghei ad. Mol Ther Oncolytics. 2021 Jan 21;20:306-324. doi: 10.1016/j.omto.2021.01.009. eCollection 2021 Mar 26. Mol Ther Oncolytics. 2021. PMID: 33614913 Free PMC article.
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