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433 results

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Partial agonism improves the anti-hyperglycaemic efficacy of an oxyntomodulin-derived GLP-1R/GCGR co-agonist.
Pickford P, Lucey M, Rujan RM, McGlone ER, Bitsi S, Ashford FB, Corrêa IR, Hodson DJ, Tomas A, Deganutti G, Reynolds CA, Owen BM, Tan TM, Minnion J, Jones B, Bloom SR. Pickford P, et al. Among authors: reynolds ca. Mol Metab. 2021 Sep;51:101242. doi: 10.1016/j.molmet.2021.101242. Epub 2021 Apr 30. Mol Metab. 2021. PMID: 33933675 Free PMC article.
A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures.
Wootten D, Reynolds CA, Koole C, Smith KJ, Mobarec JC, Simms J, Quon T, Coudrat T, Furness SG, Miller LJ, Christopoulos A, Sexton PM. Wootten D, et al. Among authors: reynolds ca. Mol Pharmacol. 2016 Mar;89(3):335-47. doi: 10.1124/mol.115.101246. Epub 2015 Dec 23. Mol Pharmacol. 2016. PMID: 26700562 Free PMC article.
The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism.
Wootten D, Reynolds CA, Smith KJ, Mobarec JC, Koole C, Savage EE, Pabreja K, Simms J, Sridhar R, Furness SGB, Liu M, Thompson PE, Miller LJ, Christopoulos A, Sexton PM. Wootten D, et al. Among authors: reynolds ca. Cell. 2016 Jun 16;165(7):1632-1643. doi: 10.1016/j.cell.2016.05.023. Cell. 2016. PMID: 27315480 Free PMC article.
Activation of the GLP-1 receptor by a non-peptidic agonist.
Zhao P, Liang YL, Belousoff MJ, Deganutti G, Fletcher MM, Willard FS, Bell MG, Christe ME, Sloop KW, Inoue A, Truong TT, Clydesdale L, Furness SGB, Christopoulos A, Wang MW, Miller LJ, Reynolds CA, Danev R, Sexton PM, Wootten D. Zhao P, et al. Among authors: reynolds ca. Nature. 2020 Jan;577(7790):432-436. doi: 10.1038/s41586-019-1902-z. Epub 2020 Jan 8. Nature. 2020. PMID: 31915381
Molecular Signature for Receptor Engagement in the Metabolic Peptide Hormone Amylin.
Bower RL, Yule L, Rees TA, Deganutti G, Hendrikse ER, Harris PWR, Kowalczyk R, Ridgway Z, Wong AG, Swierkula K, Raleigh DP, Pioszak AA, Brimble MA, Reynolds CA, Walker CS, Hay DL. Bower RL, et al. Among authors: reynolds ca. ACS Pharmacol Transl Sci. 2018 Apr 23;1(1):32-49. doi: 10.1021/acsptsci.8b00002. eCollection 2018 Sep 14. ACS Pharmacol Transl Sci. 2018. PMID: 32219203 Free PMC article.
Deconvoluting the Molecular Control of Binding and Signaling at the Amylin 3 Receptor: RAMP3 Alters Signal Propagation through Extracellular Loops of the Calcitonin Receptor.
Pham V, Zhu Y, Dal Maso E, Reynolds CA, Deganutti G, Atanasio S, Hick CA, Yang D, Christopoulos A, Hay DL, Furness SGB, Wang MW, Wootten D, Sexton PM. Pham V, et al. Among authors: reynolds ca. ACS Pharmacol Transl Sci. 2019 Mar 18;2(3):183-197. doi: 10.1021/acsptsci.9b00010. eCollection 2019 Jun 14. ACS Pharmacol Transl Sci. 2019. PMID: 32219220 Free PMC article.
433 results