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Rational siRNA design for RNA interference.
Reynolds A, Leake D, Boese Q, Scaringe S, Marshall WS, Khvorova A. Reynolds A, et al. Nat Biotechnol. 2004 Mar;22(3):326-30. doi: 10.1038/nbt936. Epub 2004 Feb 1. Nat Biotechnol. 2004. PMID: 14758366 Free article.
Mechanistic insights aid computational short interfering RNA design.
Boese Q, Leake D, Reynolds A, Read S, Scaringe SA, Marshall WS, Khvorova A. Boese Q, et al. Among authors: reynolds a. Methods Enzymol. 2005;392:73-96. doi: 10.1016/S0076-6879(04)92005-8. Methods Enzymol. 2005. PMID: 15644176
RNA interference is widely recognized for its utility as a functional genomics tool. In the absence of reliable target site selection tools, however, the impact of RNA interference (RNAi) may be diminished. ...Recently developed strategies for identification of functional …
RNA interference is widely recognized for its utility as a functional genomics tool. In the absence of reliable target site selection …
Off-target effects by siRNA can induce toxic phenotype.
Fedorov Y, Anderson EM, Birmingham A, Reynolds A, Karpilow J, Robinson K, Leake D, Marshall WS, Khvorova A. Fedorov Y, et al. Among authors: reynolds a. RNA. 2006 Jul;12(7):1188-96. doi: 10.1261/rna.28106. Epub 2006 May 8. RNA. 2006. PMID: 16682561 Free PMC article.
Functional siRNAs and miRNAs exhibit strand bias.
Khvorova A, Reynolds A, Jayasena SD. Khvorova A, et al. Among authors: reynolds a. Cell. 2003 Oct 17;115(2):209-16. doi: 10.1016/s0092-8674(03)00801-8. Cell. 2003. PMID: 14567918 Free article.
1,709 results