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Thiophene-based lipids for mRNA delivery to pulmonary and retinal tissues.
Eygeris Y, Gupta M, Kim J, Jozic A, Gautam M, Renner J, Nelson D, Bloom E, Tuttle A, Stoddard J, Reynaga R, Neuringer M, Lauer AK, Ryals RC, Sahay G. Eygeris Y, et al. Among authors: reynaga r. Proc Natl Acad Sci U S A. 2024 Mar 12;121(11):e2307813120. doi: 10.1073/pnas.2307813120. Epub 2024 Mar 4. Proc Natl Acad Sci U S A. 2024. PMID: 38437570 Free PMC article.
Development of a translatable gene augmentation therapy for CNGB1-retinitis pigmentosa.
Occelli LM, Zobel L, Stoddard J, Wagner J, Pasmanter N, Querubin J, Renner LM, Reynaga R, Winkler PA, Sun K, Marinho LFLP, O'Riordan CR, Frederick A, Lauer A, Tsang SH, Hauswirth WW, McGill TJ, Neuringer M, Michalakis S, Petersen-Jones SM. Occelli LM, et al. Among authors: reynaga r. Mol Ther. 2023 Jul 5;31(7):2028-2041. doi: 10.1016/j.ymthe.2023.04.005. Epub 2023 Apr 13. Mol Ther. 2023. PMID: 37056049 Free article.
Peptide-guided lipid nanoparticles deliver mRNA to the neural retina of rodents and nonhuman primates.
Herrera-Barrera M, Ryals RC, Gautam M, Jozic A, Landry M, Korzun T, Gupta M, Acosta C, Stoddard J, Reynaga R, Tschetter W, Jacomino N, Taratula O, Sun C, Lauer AK, Neuringer M, Sahay G. Herrera-Barrera M, et al. Among authors: reynaga r. Sci Adv. 2023 Jan 13;9(2):eadd4623. doi: 10.1126/sciadv.add4623. Epub 2023 Jan 11. Sci Adv. 2023. PMID: 36630502 Free PMC article.