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Progress in targeting the BCL-2 family of proteins.
Garner TP, Lopez A, Reyna DE, Spitz AZ, Gavathiotis E. Garner TP, et al. Among authors: reyna de. Curr Opin Chem Biol. 2017 Aug;39:133-142. doi: 10.1016/j.cbpa.2017.06.014. Epub 2017 Aug 17. Curr Opin Chem Biol. 2017. PMID: 28735187 Free PMC article. Review.
Eltrombopag directly inhibits BAX and prevents cell death.
Spitz AZ, Zacharioudakis E, Reyna DE, Garner TP, Gavathiotis E. Spitz AZ, et al. Among authors: reyna de. Nat Commun. 2021 Feb 18;12(1):1134. doi: 10.1038/s41467-021-21224-1. Nat Commun. 2021. PMID: 33602934 Free PMC article.
Direct and selective small-molecule activation of proapoptotic BAX.
Gavathiotis E, Reyna DE, Bellairs JA, Leshchiner ES, Walensky LD. Gavathiotis E, et al. Among authors: reyna de. Nat Chem Biol. 2012 Jul;8(7):639-45. doi: 10.1038/nchembio.995. Epub 2012 May 27. Nat Chem Biol. 2012. PMID: 22634637 Free PMC article.
An interconnected hierarchical model of cell death regulation by the BCL-2 family.
Chen HC, Kanai M, Inoue-Yamauchi A, Tu HC, Huang Y, Ren D, Kim H, Takeda S, Reyna DE, Chan PM, Ganesan YT, Liao CP, Gavathiotis E, Hsieh JJ, Cheng EH. Chen HC, et al. Among authors: reyna de. Nat Cell Biol. 2015 Oct;17(10):1270-81. doi: 10.1038/ncb3236. Epub 2015 Sep 7. Nat Cell Biol. 2015. PMID: 26344567 Free PMC article.
Self-regulation of BAX-induced cell death.
Reyna DE, Gavathiotis E. Reyna DE, et al. Oncotarget. 2016 Oct 11;7(41):66326-66327. doi: 10.18632/oncotarget.11948. Oncotarget. 2016. PMID: 27626173 Free PMC article. No abstract available.
Pulling the BAX trigger for tumor cell death.
Reyna DE, Gavathiotis E. Reyna DE, et al. Oncotarget. 2018 Jan 12;9(9):8204-8205. doi: 10.18632/oncotarget.24201. eCollection 2018 Feb 2. Oncotarget. 2018. PMID: 29492188 Free PMC article. No abstract available.
Small-molecule allosteric inhibitors of BAX.
Garner TP, Amgalan D, Reyna DE, Li S, Kitsis RN, Gavathiotis E. Garner TP, et al. Among authors: reyna de. Nat Chem Biol. 2019 Apr;15(4):322-330. doi: 10.1038/s41589-018-0223-0. Epub 2019 Feb 4. Nat Chem Biol. 2019. PMID: 30718816 Free PMC article.
19 results