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All-atom simulation of the HET-s prion replication.
Terruzzi L, Spagnolli G, Boldrini A, Requena JR, Biasini E, Faccioli P. Terruzzi L, et al. Among authors: requena jr. PLoS Comput Biol. 2020 Sep 18;16(9):e1007922. doi: 10.1371/journal.pcbi.1007922. eCollection 2020 Sep. PLoS Comput Biol. 2020. PMID: 32946455 Free PMC article.
An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein.
Stincardini C, Massignan T, Biggi S, Elezgarai SR, Sangiovanni V, Vanni I, Pancher M, Adami V, Moreno J, Stravalaci M, Maietta G, Gobbi M, Negro A, Requena JR, Castilla J, Nonno R, Biasini E. Stincardini C, et al. Among authors: requena jr. PLoS One. 2017 Aug 7;12(8):e0182589. doi: 10.1371/journal.pone.0182589. eCollection 2017. PLoS One. 2017. PMID: 28787011 Free PMC article.
Ok Google, how could I design therapeutics against prion diseases?
Rigoli M, Spagnolli G, Faccioli P, Requena JR, Biasini E. Rigoli M, et al. Among authors: requena jr. Curr Opin Pharmacol. 2019 Feb;44:39-45. doi: 10.1016/j.coph.2019.03.015. Epub 2019 May 3. Curr Opin Pharmacol. 2019. PMID: 31059982 Review.
Full atomistic model of prion structure and conversion.
Spagnolli G, Rigoli M, Orioli S, Sevillano AM, Faccioli P, Wille H, Biasini E, Requena JR. Spagnolli G, et al. Among authors: requena jr. PLoS Pathog. 2019 Jul 11;15(7):e1007864. doi: 10.1371/journal.ppat.1007864. eCollection 2019 Jul. PLoS Pathog. 2019. PMID: 31295325 Free PMC article.
The protean prion protein.
Requena JR. Requena JR. PLoS Biol. 2020 Jun 25;18(6):e3000754. doi: 10.1371/journal.pbio.3000754. eCollection 2020 Jun. PLoS Biol. 2020. PMID: 32584805 Free PMC article.
Understanding prion structure and conversion.
Spagnolli G, Requena JR, Biasini E. Spagnolli G, et al. Among authors: requena jr. Prog Mol Biol Transl Sci. 2020;175:19-30. doi: 10.1016/bs.pmbts.2020.07.005. Epub 2020 Sep 11. Prog Mol Biol Transl Sci. 2020. PMID: 32958233 Review.
Modeling PrPSc Generation Through Deformed Templating.
Spagnolli G, Rigoli M, Novi Inverardi G, Codeseira YB, Biasini E, Requena JR. Spagnolli G, et al. Among authors: requena jr. Front Bioeng Biotechnol. 2020 Oct 6;8:590501. doi: 10.3389/fbioe.2020.590501. eCollection 2020. Front Bioeng Biotechnol. 2020. PMID: 33123520 Free PMC article.
Pharmacological inactivation of the prion protein by targeting a folding intermediate.
Spagnolli G, Massignan T, Astolfi A, Biggi S, Rigoli M, Brunelli P, Libergoli M, Ianeselli A, Orioli S, Boldrini A, Terruzzi L, Bonaldo V, Maietta G, Lorenzo NL, Fernandez LC, Codeseira YB, Tosatto L, Linsenmeier L, Vignoli B, Petris G, Gasparotto D, Pennuto M, Guella G, Canossa M, Altmeppen HC, Lolli G, Biressi S, Pastor MM, Requena JR, Mancini I, Barreca ML, Faccioli P, Biasini E. Spagnolli G, et al. Among authors: requena jr. Commun Biol. 2021 Jan 12;4(1):62. doi: 10.1038/s42003-020-01585-x. Commun Biol. 2021. PMID: 33437023 Free PMC article.
The Structure of Mammalian Prions and Their Aggregates.
Vázquez-Fernández E, Young HS, Requena JR, Wille H. Vázquez-Fernández E, et al. Among authors: requena jr. Int Rev Cell Mol Biol. 2017;329:277-301. doi: 10.1016/bs.ircmb.2016.08.013. Epub 2016 Oct 22. Int Rev Cell Mol Biol. 2017. PMID: 28109330 Review.
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