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Ok Google, how could I design therapeutics against prion diseases?
Rigoli M, Spagnolli G, Faccioli P, Requena JR, Biasini E. Rigoli M, et al. Among authors: requena jr. Curr Opin Pharmacol. 2019 Feb;44:39-45. doi: 10.1016/j.coph.2019.03.015. Epub 2019 May 3. Curr Opin Pharmacol. 2019. PMID: 31059982 Review.
An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein.
Stincardini C, Massignan T, Biggi S, Elezgarai SR, Sangiovanni V, Vanni I, Pancher M, Adami V, Moreno J, Stravalaci M, Maietta G, Gobbi M, Negro A, Requena JR, Castilla J, Nonno R, Biasini E. Stincardini C, et al. Among authors: requena jr. PLoS One. 2017 Aug 7;12(8):e0182589. doi: 10.1371/journal.pone.0182589. eCollection 2017. PLoS One. 2017. PMID: 28787011 Free PMC article.
Cofactors influence the biological properties of infectious recombinant prions.
Fernández-Borges N, Di Bari MA, Eraña H, Sánchez-Martín M, Pirisinu L, Parra B, Elezgarai SR, Vanni I, López-Moreno R, Vaccari G, Venegas V, Charco JM, Gil D, Harrathi C, D'Agostino C, Agrimi U, Mayoral T, Requena JR, Nonno R, Castilla J. Fernández-Borges N, et al. Among authors: requena jr. Acta Neuropathol. 2018 Feb;135(2):179-199. doi: 10.1007/s00401-017-1782-y. Epub 2017 Nov 1. Acta Neuropathol. 2018. PMID: 29094186
Full atomistic model of prion structure and conversion.
Spagnolli G, Rigoli M, Orioli S, Sevillano AM, Faccioli P, Wille H, Biasini E, Requena JR. Spagnolli G, et al. Among authors: requena jr. PLoS Pathog. 2019 Jul 11;15(7):e1007864. doi: 10.1371/journal.ppat.1007864. eCollection 2019 Jul. PLoS Pathog. 2019. PMID: 31295325 Free PMC article.
The protean prion protein.
Requena JR. Requena JR. PLoS Biol. 2020 Jun 25;18(6):e3000754. doi: 10.1371/journal.pbio.3000754. eCollection 2020 Jun. PLoS Biol. 2020. PMID: 32584805 Free PMC article.
All-atom simulation of the HET-s prion replication.
Terruzzi L, Spagnolli G, Boldrini A, Requena JR, Biasini E, Faccioli P. Terruzzi L, et al. Among authors: requena jr. PLoS Comput Biol. 2020 Sep 18;16(9):e1007922. doi: 10.1371/journal.pcbi.1007922. eCollection 2020 Sep. PLoS Comput Biol. 2020. PMID: 32946455 Free PMC article.
Understanding prion structure and conversion.
Spagnolli G, Requena JR, Biasini E. Spagnolli G, et al. Among authors: requena jr. Prog Mol Biol Transl Sci. 2020;175:19-30. doi: 10.1016/bs.pmbts.2020.07.005. Epub 2020 Sep 11. Prog Mol Biol Transl Sci. 2020. PMID: 32958233 Review.
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