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Modelling of the blood-brain barrier in drug discovery and development.
Nat Rev Drug Discov. 2007 Aug;6(8):650-61. doi: 10.1038/nrd2368.
Nat Rev Drug Discov. 2007.
PMID: 17667956
Review.
Prediction of drug transport through the blood-brain barrier in vivo: a comparison between two in vitro cell models.
Lundquist S, Renftel M, Brillault J, Fenart L, Cecchelli R, Dehouck MP.
Lundquist S, et al. Among authors: renftel m.
Pharm Res. 2002 Jul;19(7):976-81. doi: 10.1023/a:1016462205267.
Pharm Res. 2002.
PMID: 12180550
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In vitro blood-brain barrier permeability and cerebral endothelial cell uptake of the neuroprotective nitrone compound NXY-059 in normoxic, hypoxic and ischemic conditions.
Dehouck MP, Cecchelli R, Richard Green A, Renftel M, Lundquist S.
Dehouck MP, et al. Among authors: renftel m.
Brain Res. 2002 Nov 15;955(1-2):229-35. doi: 10.1016/s0006-8993(02)03469-8.
Brain Res. 2002.
PMID: 12419541
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The use of in vitro cell culture models for mechanistic studies and as permeability screens for the blood-brain barrier in the pharmaceutical industry--background and current status in the drug discovery process.
Lundquist S, Renftel M.
Lundquist S, et al. Among authors: renftel m.
Vascul Pharmacol. 2002 Jun;38(6):355-64. doi: 10.1016/s1537-1891(02)00203-3.
Vascul Pharmacol. 2002.
PMID: 12529930
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Cerebrovascular protection as a possible mechanism for the protective effects of NXY-059 in preclinical models: an in vitro study.
Culot M, Mysiorek C, Renftel M, Roussel BD, Hommet Y, Vivien D, Cecchelli R, Fenart L, Berezowski V, Dehouck MP, Lundquist S.
Culot M, et al. Among authors: renftel m.
Brain Res. 2009 Oct 19;1294:144-52. doi: 10.1016/j.brainres.2009.07.035. Epub 2009 Jul 23.
Brain Res. 2009.
PMID: 19631615
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A simple method for assessing free brain/free plasma ratios using an in vitro model of the blood brain barrier.
Culot M, Fabulas-da Costa A, Sevin E, Szorath E, Martinsson S, Renftel M, Hongmei Y, Cecchelli R, Lundquist S.
Culot M, et al. Among authors: renftel m.
PLoS One. 2013 Dec 3;8(12):e80634. doi: 10.1371/journal.pone.0080634. eCollection 2013.
PLoS One. 2013.
PMID: 24312489
Free PMC article.
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