Renaud JP - Search Results

1

Cryo-EM in drug discovery: achievements, limitations and prospects.

Renaud JP, Chari A, Ciferri C, Liu WT, Rémigy HW, Stark H, Wiesmann C. Renaud JP, et al. Nat Rev Drug Discov. 2018 Jul;17(7):471-492. doi: 10.1038/nrd.2018.77. Epub 2018 Jun 8. Nat Rev Drug Discov. 2018. PMID: 29880918 Review.

2

Biophysics in drug discovery: impact, challenges and opportunities.

Renaud JP, Chung CW, Danielson UH, Egner U, Hennig M, Hubbard RE, Nar H. Renaud JP, et al. Nat Rev Drug Discov. 2016 Oct;15(10):679-98. doi: 10.1038/nrd.2016.123. Epub 2016 Aug 12. Nat Rev Drug Discov. 2016. PMID: 27516170 Free article. Review.

3

Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid.

Renaud JP, Rochel N, Ruff M, Vivat V, Chambon P, Gronemeyer H, Moras D. Renaud JP, et al. Nature. 1995 Dec 14;378(6558):681-9. doi: 10.1038/378681a0. Nature. 1995. PMID: 7501014

4

In silico fragment-based drug discovery: setup and validation of a fragment-to-lead computational protocol using S4MPLE.

Hoffer L, Renaud JP, Horvath D. Hoffer L, et al. Among authors: renaud jp. J Chem Inf Model. 2013 Apr 22;53(4):836-51. doi: 10.1021/ci4000163. Epub 2013 Apr 11. J Chem Inf Model. 2013. PMID: 23537132

5

Biophysical techniques for ligand screening and drug design.

Renaud JP, Delsuc MA. Renaud JP, et al. Curr Opin Pharmacol. 2009 Oct;9(5):622-8. doi: 10.1016/j.coph.2009.06.008. Epub 2009 Jul 4. Curr Opin Pharmacol. 2009. PMID: 19581126 Review.

6

One Question, Multiple Answers: Biochemical and Biophysical Screening Methods Retrieve Deviating Fragment Hit Lists.

Schiebel J, Radeva N, Köster H, Metz A, Krotzky T, Kuhnert M, Diederich WE, Heine A, Neumann L, Atmanene C, Roecklin D, Vivat-Hannah V, Renaud JP, Meinecke R, Schlinck N, Sitte A, Popp F, Zeeb M, Klebe G. Schiebel J, et al. Among authors: renaud jp. ChemMedChem. 2015 Sep;10(9):1511-21. doi: 10.1002/cmdc.201500267. Epub 2015 Aug 10. ChemMedChem. 2015. PMID: 26259992

7

All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta.

Stehlin-Gaon C, Willmann D, Zeyer D, Sanglier S, Van Dorsselaer A, Renaud JP, Moras D, Schüle R. Stehlin-Gaon C, et al. Among authors: renaud jp. Nat Struct Biol. 2003 Oct;10(10):820-5. doi: 10.1038/nsb979. Epub 2003 Sep 7. Nat Struct Biol. 2003. PMID: 12958591

8

A canonical structure for the ligand-binding domain of nuclear receptors.

Wurtz JM, Bourguet W, Renaud JP, Vivat V, Chambon P, Moras D, Gronemeyer H. Wurtz JM, et al. Among authors: renaud jp. Nat Struct Biol. 1996 Jan;3(1):87-94. doi: 10.1038/nsb0196-87. Nat Struct Biol. 1996. PMID: 8548460

9

Purification of the human RARgamma ligand-binding domain and crystallization of its complex with all-trans retinoic acid.

Rochel N, Renaud JP, Ruff M, Vivat V, Granger F, Bonnier D, Lerouge T, Chambon P, Gronemeyer H, Moras D. Rochel N, et al. Among authors: renaud jp. Biochem Biophys Res Commun. 1997 Jan 13;230(2):293-6. doi: 10.1006/bbrc.1996.5787. Biochem Biophys Res Commun. 1997. PMID: 9016769

10

Conformational adaptation of agonists to the human nuclear receptor RAR gamma.

Klaholz BP, Renaud JP, Mitschler A, Zusi C, Chambon P, Gronemeyer H, Moras D. Klaholz BP, et al. Among authors: renaud jp. Nat Struct Biol. 1998 Mar;5(3):199-202. doi: 10.1038/nsb0398-199. Nat Struct Biol. 1998. PMID: 9501913 No abstract available.

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