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13,179 results

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ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism.
Kawatani K, Holm ML, Starling SC, Martens YA, Zhao J, Lu W, Ren Y, Li Z, Jiang P, Jiang Y, Baker SK, Wang N, Roy B, Parsons TM, Perkerson RB 3rd, Bao H, Han X, Bu G, Kanekiyo T. Kawatani K, et al. Among authors: ren y. Mol Psychiatry. 2023 Dec 22. doi: 10.1038/s41380-023-02372-w. Online ahead of print. Mol Psychiatry. 2023. PMID: 38135757
Lipocalin-2 protects the brain during inflammatory conditions.
Kang SS, Ren Y, Liu CC, Kurti A, Baker KE, Bu G, Asmann Y, Fryer JD. Kang SS, et al. Among authors: ren y. Mol Psychiatry. 2018 Feb;23(2):344-350. doi: 10.1038/mp.2016.243. Epub 2017 Jan 10. Mol Psychiatry. 2018. PMID: 28070126 Free PMC article.
Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study.
Pottier C, Zhou X, Perkerson RB 3rd, Baker M, Jenkins GD, Serie DJ, Ghidoni R, Benussi L, Binetti G, López de Munain A, Zulaica M, Moreno F, Le Ber I, Pasquier F, Hannequin D, Sánchez-Valle R, Antonell A, Lladó A, Parsons TM, Finch NA, Finger EC, Lippa CF, Huey ED, Neumann M, Heutink P, Synofzik M, Wilke C, Rissman RA, Slawek J, Sitek E, Johannsen P, Nielsen JE, Ren Y, van Blitterswijk M, DeJesus-Hernandez M, Christopher E, Murray ME, Bieniek KF, Evers BM, Ferrari C, Rollinson S, Richardson A, Scarpini E, Fumagalli GG, Padovani A, Hardy J, Momeni P, Ferrari R, Frangipane F, Maletta R, Anfossi M, Gallo M, Petrucelli L, Suh E, Lopez OL, Wong TH, van Rooij JGJ, Seelaar H, Mead S, Caselli RJ, Reiman EM, Noel Sabbagh M, Kjolby M, Nykjaer A, Karydas AM, Boxer AL, Grinberg LT, Grafman J, Spina S, Oblak A, Mesulam MM, Weintraub S, Geula C, Hodges JR, Piguet O, Brooks WS, Irwin DJ, Trojanowski JQ, Lee EB, Josephs KA, Parisi JE, Ertekin-Taner N, Knopman DS, Nacmias B, Piaceri I, Bagnoli S, Sorbi S, Gearing M, Glass J, Beach TG, Black SE, Masellis M, Rogaeva E, Vonsattel JP, Honig LS, Kofler J, Bruni AC, Snowden J, Mann D, Pickering-Brown S, Diehl-Schmid J, Winkelmann J, Galimberti D,… See abstract for full author list ➔ Pottier C, et al. Among authors: ren y. Lancet Neurol. 2018 Jun;17(6):548-558. doi: 10.1016/S1474-4422(18)30126-1. Epub 2018 Apr 30. Lancet Neurol. 2018. PMID: 29724592 Free PMC article.
ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain.
Aikawa T, Ren Y, Yamazaki Y, Tachibana M, Johnson MR, Anderson CT, Martens YA, Holm ML, Asmann YW, Saito T, Saido TC, Fitzgerald ML, Bu G, Kanekiyo T. Aikawa T, et al. Among authors: ren y. Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23790-23796. doi: 10.1073/pnas.1908529116. Epub 2019 Nov 5. Proc Natl Acad Sci U S A. 2019. PMID: 31690660 Free PMC article.
APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid.
Zhao N, Attrebi ON, Ren Y, Qiao W, Sonustun B, Martens YA, Meneses AD, Li F, Shue F, Zheng J, Van Ingelgom AJ, Davis MD, Kurti A, Knight JA, Linares C, Chen Y, Delenclos M, Liu CC, Fryer JD, Asmann YW, McLean PJ, Dickson DW, Ross OA, Bu G. Zhao N, et al. Among authors: ren y. Sci Transl Med. 2020 Feb 5;12(529):eaay1809. doi: 10.1126/scitranslmed.aay1809. Sci Transl Med. 2020. PMID: 32024798 Free PMC article.
Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways.
Zhao N, Ren Y, Yamazaki Y, Qiao W, Li F, Felton LM, Mahmoudiandehkordi S, Kueider-Paisley A, Sonoustoun B, Arnold M, Shue F, Zheng J, Attrebi ON, Martens YA, Li Z, Bastea L, Meneses AD, Chen K, Thompson JW, St John-Williams L, Tachibana M, Aikawa T, Oue H, Job L, Yamazaki A, Liu CC, Storz P, Asmann YW, Ertekin-Taner N, Kanekiyo T, Kaddurah-Daouk R, Bu G. Zhao N, et al. Among authors: ren y. Neuron. 2020 Jun 3;106(5):727-742.e6. doi: 10.1016/j.neuron.2020.02.034. Epub 2020 Mar 20. Neuron. 2020. PMID: 32199103 Free PMC article.
Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies.
Zhou X, Nicholson AM, Ren Y, Brooks M, Jiang P, Zuberi A, Phuoc HN, Perkerson RB, Matchett B, Parsons TM, Finch NA, Lin W, Qiao W, Castanedes-Casey M, Phillips V, Librero AL, Asmann Y, Bu G, Murray ME, Lutz C, Dickson DW, Rademakers R. Zhou X, et al. Among authors: ren y. Brain. 2020 Jun 1;143(6):1905-1919. doi: 10.1093/brain/awaa141. Brain. 2020. PMID: 32504082 Free PMC article.
APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids.
Zhao J, Fu Y, Yamazaki Y, Ren Y, Davis MD, Liu CC, Lu W, Wang X, Chen K, Cherukuri Y, Jia L, Martens YA, Job L, Shue F, Nguyen TT, Younkin SG, Graff-Radford NR, Wszolek ZK, Brafman DA, Asmann YW, Ertekin-Taner N, Kanekiyo T, Bu G. Zhao J, et al. Among authors: ren y. Nat Commun. 2020 Nov 2;11(1):5540. doi: 10.1038/s41467-020-19264-0. Nat Commun. 2020. PMID: 33139712 Free PMC article.
Vascular ApoE4 Impairs Behavior by Modulating Gliovascular Function.
Yamazaki Y, Liu CC, Yamazaki A, Shue F, Martens YA, Chen Y, Qiao W, Kurti A, Oue H, Ren Y, Li Y, Aikawa T, Cherukuri Y, Fryer JD, Asmann YW, Kim BYS, Kanekiyo T, Bu G. Yamazaki Y, et al. Among authors: ren y. Neuron. 2021 Feb 3;109(3):438-447.e6. doi: 10.1016/j.neuron.2020.11.019. Epub 2020 Dec 14. Neuron. 2021. PMID: 33321072 Free PMC article.
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