Ren J - Search Results

1

Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5.

Wang G, Liu Z, Chen T, Wang Z, Yang H, Zheng M, Ren J, Tian G, Yang X, Li L, Li J, Suo J, Zhang R, Jiang X, Terrett NK, Shen J, Xu Y, Jiang H. Wang G, et al. Among authors: ren j. J Med Chem. 2012 Dec 13;55(23):10540-50. doi: 10.1021/jm301159y. Epub 2012 Nov 19. J Med Chem. 2012. PMID: 23137303

2

[Progress in the fragment-based drug discovery].

Ren J, Li J, Shi F, Wang X, He JH, Xu YC, Zhang NX, Xiong B, Shen JK. Ren J, et al. Yao Xue Xue Bao. 2013 Jan;48(1):14-24. Yao Xue Xue Bao. 2013. PMID: 23600136 Review. Chinese.

3

Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5.

Gong X, Wang G, Ren J, Liu Z, Wang Z, Chen T, Yang X, Jiang X, Shen J, Jiang H, Aisa HA, Xu Y, Li J. Gong X, et al. Among authors: ren j. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4944-7. doi: 10.1016/j.bmcl.2013.06.062. Epub 2013 Jun 29. Bioorg Med Chem Lett. 2013. PMID: 23867165

4

Thermodynamic and structural characterization of halogen bonding in protein-ligand interactions: a case study of PDE5 and its inhibitors.

Ren J, He Y, Chen W, Chen T, Wang G, Wang Z, Xu Z, Luo X, Zhu W, Jiang H, Shen J, Xu Y. Ren J, et al. J Med Chem. 2014 Apr 24;57(8):3588-93. doi: 10.1021/jm5002315. Epub 2014 Apr 15. J Med Chem. 2014. PMID: 24702184

5

Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization.

Ren J, Li J, Wang Y, Chen W, Shen A, Liu H, Chen D, Cao D, Li Y, Zhang N, Xu Y, Geng M, He J, Xiong B, Shen J. Ren J, et al. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2525-9. doi: 10.1016/j.bmcl.2014.03.100. Epub 2014 Apr 8. Bioorg Med Chem Lett. 2014. PMID: 24751441

6

Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.

Chen D, Shen A, Li J, Shi F, Chen W, Ren J, Liu H, Xu Y, Wang X, Yang X, Sun Y, Yang M, He J, Wang Y, Zhang L, Huang M, Geng M, Xiong B, Shen J. Chen D, et al. Among authors: ren j. Eur J Med Chem. 2014 Nov 24;87:765-81. doi: 10.1016/j.ejmech.2014.09.065. Epub 2014 Sep 22. Eur J Med Chem. 2014. PMID: 25313505

7

Structure-Based Discovery of PDEs Inhibitors.

Li L, Chen W, Chen T, Ren J, Xu Y. Li L, et al. Among authors: ren j. Curr Top Med Chem. 2016;16(9):917-33. doi: 10.2174/1568026615666150825142134. Curr Top Med Chem. 2016. PMID: 26303429 Review.

8

Combinatorial Pharmacophore Modeling of Multidrug and Toxin Extrusion Transporter 1 Inhibitors: a Theoretical Perspective for Understanding Multiple Inhibitory Mechanisms.

Xu Y, Liu X, Wang Y, Zhou N, Peng J, Gong L, Ren J, Luo C, Luo X, Jiang H, Chen K, Zheng M. Xu Y, et al. Among authors: ren j. Sci Rep. 2015 Sep 2;5:13684. doi: 10.1038/srep13684. Sci Rep. 2015. PMID: 26330298 Free PMC article.

9

Novel 2H-chromen-2-one derivatives of resveratrol: Design, synthesis, modeling and use as human monoamine oxidase inhibitors.

Ruan BF, Cheng HJ, Ren J, Li HL, Guo LL, Zhang XX, Liao C. Ruan BF, et al. Among authors: ren j. Eur J Med Chem. 2015 Oct 20;103:185-90. doi: 10.1016/j.ejmech.2015.08.055. Epub 2015 Sep 1. Eur J Med Chem. 2015. PMID: 26352677

10

Design and synthesis of benzylpiperidine inhibitors targeting the menin-MLL1 interface.

Ren J, Xu W, Tang L, Su M, Chen D, Chen YL, Zang Y, Li J, Shen J, Zhou Y, Xiong B. Ren J, et al. Bioorg Med Chem Lett. 2016 Sep 15;26(18):4472-4476. doi: 10.1016/j.bmcl.2016.07.074. Epub 2016 Aug 2. Bioorg Med Chem Lett. 2016. PMID: 27528435

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