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Synthesis and study of cytotoxic activity of 1,2,4-trioxane- and egonol-derived hybrid molecules against Plasmodium falciparum and multidrug-resistant human leukemia cells.
Reiter C, Capcı Karagöz A, Fröhlich T, Klein V, Zeino M, Viertel K, Held J, Mordmüller B, Emirdağ Öztürk S, Anıl H, Efferth T, Tsogoeva SB. Reiter C, et al. Eur J Med Chem. 2014 Mar 21;75:403-12. doi: 10.1016/j.ejmech.2014.01.043. Epub 2014 Jan 31. Eur J Med Chem. 2014. PMID: 24561670
Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin.
Çapcı Karagöz A, Reiter C, Seo EJ, Gruber L, Hahn F, Leidenberger M, Klein V, Hampel F, Friedrich O, Marschall M, Kappes B, Efferth T, Tsogoeva SB. Çapcı Karagöz A, et al. Among authors: reiter c. Bioorg Med Chem. 2018 Jul 23;26(12):3610-3618. doi: 10.1016/j.bmc.2018.05.041. Epub 2018 May 24. Bioorg Med Chem. 2018. PMID: 29887512
The broad-spectrum antiinfective drug artesunate interferes with the canonical nuclear factor kappa B (NF-κB) pathway by targeting RelA/p65.
Hutterer C, Niemann I, Milbradt J, Fröhlich T, Reiter C, Kadioglu O, Bahsi H, Zeitträger I, Wagner S, Einsiedel J, Gmeiner P, Vogel N, Wandinger S, Godl K, Stamminger T, Efferth T, Tsogoeva SB, Marschall M. Hutterer C, et al. Among authors: reiter c. Antiviral Res. 2015 Dec;124:101-9. doi: 10.1016/j.antiviral.2015.10.003. Epub 2015 Nov 4. Antiviral Res. 2015. PMID: 26546752
328 results