Reichel A - Search Results

1

Unbound Brain-to-Plasma Partition Coefficient, K_p,uu,brain-a Game Changing Parameter for CNS Drug Discovery and Development.

Loryan I, Reichel A, Feng B, Bundgaard C, Shaffer C, Kalvass C, Bednarczyk D, Morrison D, Lesuisse D, Hoppe E, Terstappen GC, Fischer H, Di L, Colclough N, Summerfield S, Buckley ST, Maurer TS, Fridén M. Loryan I, et al. Among authors: reichel a. Pharm Res. 2022 Jul;39(7):1321-1341. doi: 10.1007/s11095-022-03246-6. Epub 2022 Apr 11. Pharm Res. 2022. PMID: 35411506 Free PMC article.

2

Potential of immobilized artificial membranes for predicting drug penetration across the blood-brain barrier.

Reichel A, Begley DJ. Reichel A, et al. Pharm Res. 1998 Aug;15(8):1270-4. doi: 10.1023/a:1011904311149. Pharm Res. 1998. PMID: 9706060

3

Addressing central nervous system (CNS) penetration in drug discovery: basics and implications of the evolving new concept.

Reichel A. Reichel A. Chem Biodivers. 2009 Nov;6(11):2030-49. doi: 10.1002/cbdv.200900103. Chem Biodivers. 2009. PMID: 19937839 Review.

4

The role of blood-brain barrier studies in the pharmaceutical industry.

Reichel A. Reichel A. Curr Drug Metab. 2006 Feb;7(2):183-203. doi: 10.2174/138920006775541525. Curr Drug Metab. 2006. PMID: 16472107 Review.

5

Pharmacokinetics in Drug Discovery: An Exposure-Centred Approach to Optimising and Predicting Drug Efficacy and Safety.

Reichel A, Lienau P. Reichel A, et al. Handb Exp Pharmacol. 2016;232:235-60. doi: 10.1007/164_2015_26. Handb Exp Pharmacol. 2016. PMID: 26330260 Review.

6

In vivo models and decision trees for formulation development in early drug development: A review of current practices and recommendations for biopharmaceutical development.

Zane P, Gieschen H, Kersten E, Mathias N, Ollier C, Johansson P, Van den Bergh A, Van Hemelryck S, Reichel A, Rotgeri A, Schäfer K, Müllertz A, Langguth P. Zane P, et al. Among authors: reichel a. Eur J Pharm Biopharm. 2019 Sep;142:222-231. doi: 10.1016/j.ejpb.2019.06.010. Epub 2019 Jun 21. Eur J Pharm Biopharm. 2019. PMID: 31233862 Review.

7

Concentration Dependence of the Unbound Partition Coefficient Kp_uu and Its Application to Correct for Exposure-Related Discrepancies between Biochemical and Cellular Potency of KAT6A Inhibitors.

Trünkle C, Lechner C, Korr D, Bouché L, Barak N, Fernández-Montalván A, Süssmuth RD, Reichel A. Trünkle C, et al. Among authors: reichel a. Drug Metab Dispos. 2020 Jul;48(7):553-562. doi: 10.1124/dmd.120.090563. Epub 2020 May 1. Drug Metab Dispos. 2020. PMID: 32357973

8

Extension of the Mechanistic Tissue Distribution Model of Rodgers and Rowland by Systematic Incorporation of Lysosomal Trapping: Impact on Unbound Partition Coefficient and Volume of Distribution Predictions in the Rat.

Schmitt MV, Reichel A, Liu X, Fricker G, Lienau P. Schmitt MV, et al. Among authors: reichel a. Drug Metab Dispos. 2021 Jan;49(1):53-61. doi: 10.1124/dmd.120.000161. Epub 2020 Nov 4. Drug Metab Dispos. 2021. PMID: 33148688

9

An overview of in vitro techniques for blood-brain barrier studies.

Reichel A, Begley DJ, Abbott NJ. Reichel A, et al. Methods Mol Med. 2003;89:307-24. doi: 10.1385/1-59259-419-0:307. Methods Mol Med. 2003. PMID: 12958429 Review. No abstract available.

10

N-glycosylation of ABC transporters is associated with functional activity in sandwich-cultured rat hepatocytes.

Draheim V, Reichel A, Weitschies W, Moenning U. Draheim V, et al. Among authors: reichel a. Eur J Pharm Sci. 2010 Oct 9;41(2):201-9. doi: 10.1016/j.ejps.2010.06.005. Epub 2010 Jun 15. Eur J Pharm Sci. 2010. PMID: 20558284

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