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Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation.
Salamina M, Montefiore BC, Liu M, Wood DJ, Heath R, Ault JR, Wang LZ, Korolchuk S, Baslé A, Pastok MW, Reeks J, Tatum NJ, Sobott F, Arold ST, Pagano M, Noble MEM, Endicott JA. Salamina M, et al. Among authors: reeks j. J Mol Biol. 2021 Mar 5;433(5):166795. doi: 10.1016/j.jmb.2020.166795. Epub 2021 Jan 7. J Mol Biol. 2021. PMID: 33422522 Free PMC article.
Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction.
Chessari G, Hardcastle IR, Ahn JS, Anil B, Anscombe E, Bawn RH, Bevan LD, Blackburn TJ, Buck I, Cano C, Carbain B, Castro J, Cons B, Cully SJ, Endicott JA, Fazal L, Golding BT, Griffin RJ, Haggerty K, Harnor SJ, Hearn K, Hobson S, Holvey RS, Howard S, Jennings CE, Johnson CN, Lunec J, Miller DC, Newell DR, Noble MEM, Reeks J, Revill CH, Riedinger C, St Denis JD, Tamanini E, Thomas H, Thompson NT, Vinković M, Wedge SR, Williams PA, Wilsher NE, Zhang B, Zhao Y. Chessari G, et al. Among authors: reeks j. J Med Chem. 2021 Apr 8;64(7):4071-4088. doi: 10.1021/acs.jmedchem.0c02188. Epub 2021 Mar 24. J Med Chem. 2021. PMID: 33761253
Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor.
Tamanini E, Miyamura S, Buck IM, Cons BD, Dawson L, East C, Futamura T, Goto S, Griffiths-Jones C, Hashimoto T, Heightman TD, Ishikawa S, Ito H, Kaneko Y, Kawato T, Kondo K, Kurihara N, McCarthy JM, Mori Y, Nagase T, Nakaishi Y, Reeks J, Sato A, Schöpf P, Tai K, Tamai T, Tisi D, Woolford AJ. Tamanini E, et al. Among authors: reeks j. ACS Med Chem Lett. 2022 Sep 6;13(10):1591-1597. doi: 10.1021/acsmedchemlett.2c00272. eCollection 2022 Oct 13. ACS Med Chem Lett. 2022. PMID: 36262388 Free PMC article.
Fragment-based drug discovery using cryo-EM.
Saur M, Hartshorn MJ, Dong J, Reeks J, Bunkoczi G, Jhoti H, Williams PA. Saur M, et al. Among authors: reeks j. Drug Discov Today. 2020 Mar;25(3):485-490. doi: 10.1016/j.drudis.2019.12.006. Epub 2019 Dec 23. Drug Discov Today. 2020. PMID: 31877353 Free article. Review.
Structure and mechanism of the CMR complex for CRISPR-mediated antiviral immunity.
Zhang J, Rouillon C, Kerou M, Reeks J, Brugger K, Graham S, Reimann J, Cannone G, Liu H, Albers SV, Naismith JH, Spagnolo L, White MF. Zhang J, et al. Among authors: reeks j. Mol Cell. 2012 Feb 10;45(3):303-13. doi: 10.1016/j.molcel.2011.12.013. Epub 2012 Jan 5. Mol Cell. 2012. PMID: 22227115 Free PMC article.
CRISPR interference: a structural perspective.
Reeks J, Naismith JH, White MF. Reeks J, et al. Biochem J. 2013 Jul 15;453(2):155-66. doi: 10.1042/BJ20130316. Biochem J. 2013. PMID: 23805973 Free PMC article. Review.
17 results