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Oxidized analogs of Di(1H-indol-3-yl)methyl-4-substituted benzenes are NR4A1-dependent UPR inducers with potent and safe anti-cancer activity.
Sanchez M, Xia Z, Rico-Bautista E, Cao X, Cuddy M, Castro DJ, Correa RG, Chen L, Yu J, Bobkov A, Ruvolo V, Andreeff M, Oshima RG, Matsuzawa SI, Reed JC, Zhang XK, Hansel D, Wolf DA, Dawson MI. Sanchez M, et al. Among authors: reed jc. Oncotarget. 2018 May 18;9(38):25057-25074. doi: 10.18632/oncotarget.25285. eCollection 2018 May 18. Oncotarget. 2018. PMID: 29861853 Free PMC article.
Derivation of a retinoid X receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-Di(1H-indol-3-yl)methyl-4-trifluoromethylbenzene.
Dawson MI, Ye M, Cao X, Farhana L, Hu QY, Zhao Y, Xu LP, Kiselyuk A, Correa RG, Yang L, Hou T, Reed JC, Itkin-Ansari P, Levine F, Sanner MF, Fontana JA, Zhang XK. Dawson MI, et al. Among authors: reed jc. ChemMedChem. 2009 Jul;4(7):1106-19. doi: 10.1002/cmdc.200800447. ChemMedChem. 2009. PMID: 19378296 Free PMC article.
Analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid. 2. Impact of 3-chloro group replacement on inhibition of proliferation and induction of apoptosis of leukemia and cancer cell lines.
Xia Z, Correa RG, Das JK, Farhana L, Castro DJ, Yu J, Oshima RG, Fontana JA, Reed JC, Dawson MI. Xia Z, et al. Among authors: reed jc. J Med Chem. 2012 Jan 12;55(1):233-49. doi: 10.1021/jm2011436. Epub 2011 Dec 2. J Med Chem. 2012. PMID: 22136251
NLRs: Sentinels of innate immunity or cancer culprits?
Correa RG, Ware CF, Reed JC. Correa RG, et al. Among authors: reed jc. Oncoscience. 2014 May 26;1(5):308-9. doi: 10.18632/oncoscience.44. eCollection 2014. Oncoscience. 2014. PMID: 25594025 Free PMC article. No abstract available.
1,000 results